MolNFT v1 · #189764 · protein
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local
7VV4 · Mas-related G-protein coupled receptor member X2: “Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local”. Electron microscopy, 1 ligand (CLR), 2 pockets (best druggability 0.67). MolNFT v1…
- PDB
- 7VV4
- Type
- protein
- Length
- 269 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mas-related G-protein coupled receptor member X2; Circular cortistatin-14
- UniProt
- Q96LB1, O00230
- Ligands
- CLR
- Pockets
- 2 · best druggability 0.67
Structure
electron microscopy · 2 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Mas-related G-protein coupled receptor member X2 | protein | 263 | 84% helix, 0% strand | Q96LB1 |
| L | Circular cortistatin-14 | protein | 6 | 0% helix, 0% strand | O00230 |
Ligands and binding sites
- CLR · Cholesterol · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 319 | 0.67 | 0.81 | 30 | empty |
| 2 | 205 | 0.48 | 0.74 | 29 | empty |
Interfaces
1 interface between chains.
- R–L · 543 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7VV4 · Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14… · the same entry in another collection · chain R against R, TM-score 1.00
- Q96LB1 · AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member X2… · a predicted model of the same protein · chain R against A, TM-score 0.95
- O00230 · AlphaFold monomer V2.0 prediction for cortistatin (O00230) · a predicted model of the same protein · chain L against A, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96LB1
- Every structure of UniProt O00230
- Elsewhere: RCSB PDB 7VV4 · PDBe 7VV4 · UniProt Q96LB1 · UniProt O00230
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