MolNFT v1 · #189717 · protein
Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the nanodisc in E1P state.
7VSH: “Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the nanodisc in E1P state.”. Electron microscopy, 5 ligands (ALF, 17F, NAG). MolNFT v1 #189717 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7VSH
- Type
- protein
- Length
- 1,352 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q8NB49, Q9NV96
- Ligands
- ALF, 17F, NAG, MAN, MG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1028 | — | Q8NB49 |
| C | — | protein | 324 | — | Q9NV96 |
Ligands and binding sites
- ALF · Tetrafluoroaluminate ion · ligand · chains A
- 17F · O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, C
- MAN · alpha-D-mannopyranose · sugar
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7VSH · Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in E1P… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NV96 · AlphaFold monomer V2.0 prediction for cell cycle control protein 50A (Q9NV96) · a predicted model of the same protein · chain C against A, TM-score 0.93
- Q8NB49 · AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase ig (Q8NB49) · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NB49
- Every structure of UniProt Q9NV96
- Elsewhere: RCSB PDB 7VSH · PDBe 7VSH · UniProt Q8NB49 · UniProt Q9NV96
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