Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the nanodisc in E1P state.

Structure

electron microscopy · 2 distinct chains.

Ligands and binding sites

• ALF · Tetrafluoroaluminate ion · ligand · chains A
• 17F · O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, C
• MAN · alpha-D-mannopyranose · sugar
• MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7VSH · Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in E1P… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NV96 · AlphaFold monomer V2.0 prediction for cell cycle control protein 50A (Q9NV96) · a predicted model of the same protein · chain C against A, TM-score 0.93
• Q8NB49 · AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase ig (Q8NB49) · a predicted model of the same protein · chain A against A, TM-score 0.79

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8NB49
• Every structure of UniProt Q9NV96
• Elsewhere: RCSB PDB 7VSH · PDBe 7VSH · UniProt Q8NB49 · UniProt Q9NV96