UniProt Q9NV96
Cell cycle control protein 50A (Q9NV96)
Cell cycle control protein 50A (UniProt Q9NV96): 39 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 119 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9NV96
- Protein
- Cell cycle control protein 50A
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 119 · 20 records with a druggable one
Structures
40 records of Q9NV96 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6K7G | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class1) | electron microscopy | C | NAG, Y01 | — |
| 6K7G | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state CLASS1) | electron microscopy | C | NAG, Y01 | — |
| 6K7H | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state class2) | electron microscopy | C | NAG, MAN, Y01 | 6 (best 0.71) |
| 6K7H | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1 state CLASS2) | electron microscopy | C | NAG, MAN, Y01 | — |
| 6K7I | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class2) | electron microscopy | C | NAG, MAN, Y01 | 3 (best 0.73) |
| 6K7I | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state CLASS2) | electron microscopy | C | NAG, Y01 | — |
| 6K7J | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class1) | electron microscopy | C | NAG, Y01 | 5 (best 0.71) |
| 6K7J | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state CLASS1) | electron microscopy | C | NAG, Y01 | — |
| 6K7K | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP-Pi state) | electron microscopy | C | NAG, Y01 | — |
| 6K7K | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP- pi state) | electron microscopy | C | NAG, Y01 | — |
| 6K7L | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2P state class2) | electron microscopy | C | NAG, MAN, Y01 | 6 (best 0.73) |
| 6K7L | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2P state CLASS2) | electron microscopy | C | NAG, Y01 | — |
| 6K7M | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2Pi-PL state) | electron microscopy | C | NAG, MAN, Y01 | 4 (best 0.75) |
| 6K7M | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E2PI-pl state) | electron microscopy | C | NAG, MAN, Y01 | — |
| 6K7N | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1P state) | electron microscopy | C | NAG, Y01 | 5 (best 0.73) |
| 6K7N | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1P state) | electron microscopy | C | NAG, Y01 | — |
| 6LKN | Crystal structure of ATP11C-CDC50A in PtdSer-bound E2P state | x-ray diffraction | C, F, J, N | NAG | — |
| 6LKN | Crystal structure of ATP11C-CDC50A in ptdser-bound E2P state | x-ray diffraction | C, F, J, N | NAG | — |
| 7BSU | Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-bound E2BeF state | electron microscopy | C | NAG | 5 (best 0.70) |
| 7BSU | Cryo-EM structure of a human ATP11C-CDC50A flippase in ptdser-bound E2BEF state | electron microscopy | C | NAG | — |
| 7PY4 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | electron microscopy | B | NAG, Y01 | 6 (best 0.78) |
| 7PY4 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited state | electron microscopy | B | NAG, Y01 | — |
| 7VGI | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2P state | electron microscopy | A | NAG, MAN | 7 (best 0.78) |
| 7VGI | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2P state | electron microscopy | A | NAG | — |
| 7VGJ | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2Pi-PS state | electron microscopy | B | — | 9 (best 0.79) |
| 7VGJ | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2PI-ps state | electron microscopy | B | — | — |
| 7VSG | Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in… | electron microscopy | B | NAG, MAN | 5 (best 0.71) |
| 7VSG | Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the nanodisc in… | electron microscopy | B | NAG, MAN | — |
| 7VSH | Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in E1P state. | electron microscopy | C | NAG | — |
| 7VSH | Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the nanodisc in E1P state. | electron microscopy | C | NAG | — |
| 8OX4 | Cryo-EM structure of ATP8B1-CDC50A in E1-ATP conformation | electron microscopy | B | NAG | 4 (best 0.76) |
| 8OX5 | Cryo-EM structure of ATP8B1-CDC50A in E1P-ADP conformation | electron microscopy | B | NAG | 7 (best 0.76) |
| 8OX6 | Cryo-EM structure of ATP8B1-CDC50A in E1P conformation | electron microscopy | B | NAG | 8 (best 0.76) |
| 8OX7 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "closed" conformation | electron microscopy | B | NAG | 7 (best 0.76) |
| 8OX8 | Cryo-EM structure of ATP8B1-CDC50A in E2P autoinhibited "open" conformation | electron microscopy | B | NAG | 7 (best 0.77) |
| 8OX9 | Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC | electron microscopy | B | NAG | 7 (best 0.78) |
| 8OXA | Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PS | electron microscopy | B | NAG | 6 (best 0.78) |
| 8OXB | Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PC | electron microscopy | B | NAG | 6 (best 0.77) |
| 8OXC | Cryo-EM structure of ATP8B1-CDC50A in E2-Pi conformation with occluded PI | electron microscopy | B | NAG | 6 (best 0.75) |
| Q9NV96 | AlphaFold monomer V2.0 prediction for cell cycle control protein 50A (Q9NV96) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6K7N chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.78 Å
- 6K7N chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.78 Å
- 6K7I chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.73 Å
- 6K7I chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.73 Å
- 6K7K chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.70 Å
- 6K7K chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.70 Å
- 6K7M chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.82 Å
- 6K7M chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.82 Å
- 6K7J chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.85 Å
- 6K7J chain C against the predicted model Q9NV96: TM-score 0.95, RMSD 1.85 Å
Elsewhere
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