MolNFT v1 · #189342 · protein
Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human glp-1R-gs complex
7VBI: “Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human glp-1R-gs complex”. Electron microscopy. MolNFT v1 #189342 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7VBI
- Type
- protein
- Length
- 1,158 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P43220, P54311, P63212
Structure
electron microscopy · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 227 | — | — |
| N | — | protein | 126 | — | — |
| P | — | protein | 29 | — | — |
| R | — | protein | 382 | — | P43220 |
| B | — | protein | 337 | — | P54311 |
| G | — | protein | 57 | — | P63212 |
Compared structures
- 7VBI · Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs… · the same entry in another collection · chain G against G, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P43220 · AlphaFold monomer V2.0 prediction for glucagon-like peptide 1 receptor (P43220) · a predicted model of the same protein · chain R against A, TM-score 0.79
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43220
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Elsewhere: RCSB PDB 7VBI · PDBe 7VBI · UniProt P43220 · UniProt P54311 · UniProt P63212
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