MolNFT v1 · #189312 · protein
Cryo-EM structure of the ghrh-bound human ghrhr splice variant 1 complex
7V9M · Guanine nucleotide-binding protein G(S) subunit alpha…: “Cryo-EM structure of the ghrh-bound human ghrhr splice variant 1 complex”. Electron microscopy, 13 pockets (best druggability 0.81). MolNFT v1 #189312 on GenesisL1: 3D…
- PDB
- 7V9M
- Type
- protein
- Length
- 1,029 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P54311, P01286, P63212
- Pockets
- 13 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 39% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 224 | 46% helix, 19% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 8% helix, 46% strand | P54311 |
| N | Nanobody-35 | protein | 126 | 5% helix, 42% strand | — |
| P | Somatoliberin | protein | 19 | 89% helix, 0% strand | P01286 |
| R | Human growth hormone releasing hormone receptor splice variant 1(SV1) | protein | 265 | 81% helix, 0% strand | — |
| Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 60% helix, 0% strand | P63212 |
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 655 | 0.81 | 0.86 | 55 | empty |
| 2 | 1103 | 0.76 | 0.79 | 86 | empty |
| 3 | 890 | 0.76 | 0.79 | 63 | empty |
| 4 | 91 | 0.68 | 0.92 | 22 | empty |
| 5 | 225 | 0.62 | 0.82 | 33 | empty |
Interfaces
7 interfaces between chains.
- B–Y · 2359 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 1492 Ų buried · 28 hydrogen bonds · protein-protein
- P–R · 1249 Ų buried · 9 hydrogen bonds · protein-protein
- A–R · 1137 Ų buried · 10 hydrogen bonds · protein-protein
- A–N · 867 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 7V9M · Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex · the same entry in another collection · chain Y against Y, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain Y against A, TM-score 0.71
- P01286 · AlphaFold monomer V2.0 prediction for somatoliberin (P01286) · a predicted model of the same protein · chain P against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P54311
- Every structure of UniProt P01286
- Every structure of UniProt P63212
- Elsewhere: RCSB PDB 7V9M · PDBe 7V9M · UniProt P63092 · UniProt P54311 · UniProt P01286 · UniProt P63212
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