MolNFT v1 · #189143 · protein
Structure of cannabinoid receptor type 1(CB1)
7V3Z · Fusion protein of cannabinoid receptor 1 and flavodoxin: “Structure of cannabinoid receptor type 1(CB1)”. X-ray diffraction, 3 ligands (9GF, CLR, FMN), 5 pockets (best druggability 0.86). MolNFT v1 #189143 on GenesisL1: 3D…
- PDB
- 7V3Z
- Type
- protein
- Length
- 431 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein of cannabinoid receptor 1 and flavodoxin
- UniProt
- P21554, P00323
- Ligands
- 9GF, CLR, FMN
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 61% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein of cannabinoid receptor 1 and flavodoxin | protein | 431 | 61% helix, 7% strand | P21554, P00323 |
Ligands and binding sites
- 9GF · 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol · ligand · chains A
- CLR · Cholesterol · ligand · chains A
- FMN · Flavin mononucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 299 | 0.86 | 0.96 | 33 | 9GF |
| 2 | 339 | 0.57 | 0.75 | 46 | empty |
| 3 | 89 | 0.43 | 0.79 | 24 | FMN |
| 4 | 78 | 0.41 | 0.78 | 12 | empty |
| 5 | 50 | 0.34 | 0.78 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7V3Z · Structure of cannabinoid receptor type 1(CB1) · the same entry in another collection · chain A against A, TM-score 1.00
- P21554 · AlphaFold monomer V2.0 prediction for cannabinoid receptor 1 (P21554) · a predicted model of the same protein · chain A against A, TM-score 0.65
- P00323 · AlphaFold monomer V2.0 prediction for flavodoxin (P00323) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21554
- Every structure of UniProt P00323
- Elsewhere: RCSB PDB 7V3Z · PDBe 7V3Z · UniProt P21554 · UniProt P00323
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