UniProt P21554

Cannabinoid receptor 1 (P21554)

Cannabinoid receptor 1 (UniProt P21554): 29 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P21554
Protein: Cannabinoid receptor 1
Experimental structures: 29
Predicted models: 1
Ligands: 14
Pockets: 56 · 8 records with a druggable one

Structures

30 records of P21554 in the MolNFT archive: 29 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1LVQ	IC3 of CB1 Bound to G(alpha)i	solution nmr	A	—	—
1LVQ	IC3 of CB1 bound to G(ALPHA)I	solution nmr	A	—	—
1LVR	IC3 of CB1 (L431A,A432L) Bound to G(alpha)i	solution nmr	A	—	—
1LVR	IC3 of CB1 (L431A,A432L) bound to G(ALPHA)I	solution nmr	A	—	—
2B0Y	Solution Structure of a peptide mimetic of the fourth cytoplasmic loop of the G-protein coupled CB1…	solution nmr	A	—	—
2B0Y	Solution structure of a peptide mimetic of the fourth cytoplasmic loop of the G-protein coupled CB1…	solution nmr	A	—	—
2KOE	Human cannabinoid receptor 1 - helix 7/8 peptide	solution nmr	A	—	—
2KOE	Human cannabinoid receptor 1 - helix 7/8 peptide	solution nmr	A	—	—
5TGZ	Crystal Structure of the Human Cannabinoid Receptor CB1	x-ray diffraction	A	ZDG, FMN, OLA	7 (best 0.79)
5TGZ	Crystal structure of the human cannabinoid receptor CB1	x-ray diffraction	A	ZDG, FMN, OLA	—
5U09	High-resolution crystal structure of the human CB1 cannabinoid receptor	x-ray diffraction	A	SO4, 7DY	—
5XR8	Crystal structure of the human CB1 in complex with agonist AM841	x-ray diffraction	A	FMN, 8D0, CLR	—
5XRA	Crystal structure of the human CB1 in complex with agonist AM11542	x-ray diffraction	A	FMN, 8D3, OLA, CLR	5 (best 0.86)
5XRA	Crystal structure of the human CB1 in complex with agonist AM11542	x-ray diffraction	A	FMN, 8D3, OLA, CLR	—
6KPG	Cryo-EM structure of CB1-G protein complex	electron microscopy	R	8D0	—
6KPG	Cryo-EM structure of CB1-G protein complex	electron microscopy	R	8D0	—
6KQI	Structure of an allosteric modulator bound to the CB1 cannabinoid receptor	x-ray diffraction	A	9GF, 9GL, OLA	—
6KQI	Structure of an allosteric modulator bound to the CB1 cannabinoid receptor	x-ray diffraction	A	9GF, 9GL, OLA	—
6N4B	Cannabinoid receptor 1-G protein complex	electron microscopy	R	CLR	—
7FEE	Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1	x-ray diffraction	A	CLR, 9GF, 7IC, OLA	—
7FEE	Crystal structure of protein L	x-ray diffraction	A	CLR, 9GF, 7IC, OLA	—
7V3Z	Structure of cannabinoid receptor type 1(CB1)	x-ray diffraction	A	9GF, CLR, FMN	—
7V3Z	Structure of cannabinoid receptor type 1(CB1)	x-ray diffraction	A	9GF, CLR, FMN	—
7WV9	Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi…	electron microscopy	R	9GF, 7IC	6 (best 0.84)
7WV9	Cryo-EM structure of human receptor with G proteins	electron microscopy	R	9GF, 7IC	6 (best 0.84)
8IKH	Cryo-EM structure of human receptor with G proteins	electron microscopy	R	Q2L	7 (best 0.77)
9B9Y	Structural mechanism of CB1R binding to peripheral and biased inverse agonists	electron microscopy	R	7DY	8 (best 0.81)
9B9Z	Structural mechanism of CB1R binding to peripheral and biased inverse agonists	electron microscopy	R	A1AKO	8 (best 0.80)
9BA0	Structural mechanism of CB1R binding to peripheral and biased inverse agonists	electron microscopy	R	A1AKN	9 (best 0.79)
P21554	AlphaFold monomer V2.0 prediction for cannabinoid receptor 1 (P21554)	predicted	A	—	—

Ligands

9GF · 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol · in 8 records
CLR · Cholesterol · in 8 records
OLA · Oleic acid · in 8 records
FMN · Flavin mononucleotide · in 7 records
7IC · 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole · in 4 records
8D0 · (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol · in 3 records
7DY · N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide · in 2 records
8D3 · (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol · in 2 records
9GL · 5-chloro-3-ethyl-N-{2-[4-(piperidin-1-yl)phenyl]ethyl}-1H-indole-2-carboxamide · in 2 records
ZDG · 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate · in 2 records
A1AKN · N-(N-{(E)-[(4S)-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl][4-(trifluoromethyl)benzene-1-sulfonamido]methylidene}carbamimidoyl)acetamide · in 1 record
A1AKO · (4S)-3-(4-chlorophenyl)-N'-[(1E)-ethanimidoyl]-4-phenyl-N-[4-(trifluoromethyl)benzene-1-sulfonyl]-4,5-dihydro-1H-pyrazole-1-carboximidamide · in 1 record
Q2L · 3-[(1R)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1H-indole · in 1 record
SO4 · Sulfate ion · in 1 record

Experiment against prediction

5XRA chain A against the predicted model P00323: TM-score 0.34, RMSD 0.48 Å
5XRA chain A against the predicted model P00323: TM-score 0.34, RMSD 0.48 Å
5XR8 chain A against the predicted model P00323: TM-score 0.34, RMSD 0.57 Å
5TGZ chain A against the predicted model P00323: TM-score 0.33, RMSD 0.82 Å
5TGZ chain A against the predicted model P00323: TM-score 0.33, RMSD 0.82 Å
7V3Z chain A against the predicted model P00323: TM-score 0.34, RMSD 0.70 Å
7V3Z chain A against the predicted model P00323: TM-score 0.34, RMSD 0.70 Å
6KPG chain R against the predicted model P21554: TM-score 0.95, RMSD 1.53 Å
6KPG chain R against the predicted model P21554: TM-score 0.95, RMSD 1.53 Å
7WV9 chain R against the predicted model P21554: TM-score 0.94, RMSD 1.81 Å

Elsewhere

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.