UniProt P00323
Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1 (P00323)
Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1 (UniProt P00323): 67 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00323
- Protein
- Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1
- Experimental structures
- 67
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 6 · 1 record with a druggable one
Structures
68 records of P00323 in the MolNFT archive: 67 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AKQ | D95A oxidized flavodoxin mutant from D. vulgaris | x-ray diffraction | A | — | — |
| 1AKQ | D95A oxidized flavodoxin mutant from D. vulgaris | x-ray diffraction | A | — | — |
| 1AKR | G61A oxidized flavodoxin mutant | x-ray diffraction | A | — | — |
| 1AKR | G61A oxidized flavodoxin mutant | x-ray diffraction | A | — | — |
| 1AKT | G61N oxidized flavodoxin mutant | x-ray diffraction | A | — | — |
| 1AKT | G61N oxidized flavodoxin mutant | x-ray diffraction | A | — | — |
| 1AKU | D95A hydroquinone flavodoxin mutant from D. vulgaris | x-ray diffraction | A | — | — |
| 1AKU | D95A hydroquinone flavodoxin mutant from D. vulgaris | x-ray diffraction | A | — | — |
| 1AKV | D95A semiquinone flavodoxin mutant from D. vulgaris | x-ray diffraction | A | — | — |
| 1AKV | D95A semiquinone flavodoxin mutant from D. vulgaris | x-ray diffraction | A | — | — |
| 1AKW | G61L oxidized flavodoxin mutant | x-ray diffraction | A | — | — |
| 1AKW | G61L oxidized flavodoxin mutant | x-ray diffraction | A | — | — |
| 1AZL | G61V flavodoxin mutant from desulfovibrio vulgaris | x-ray diffraction | A | — | — |
| 1AZL | G61V flavodoxin mutant from desulfovibrio vulgaris | x-ray diffraction | A | — | — |
| 1BU5 | X-ray crystal structure of the desulfovibrio vulgaris (hildenborough) apoflavodoxin-riboflavin… | x-ray diffraction | A | — | — |
| 1BU5 | X-ray crystal structure of the desulfovibrio vulgaris (hildenborough) apoflavodoxin-riboflavin… | x-ray diffraction | A | — | — |
| 1C7E | D95E hydroquinone flavodoxin mutant from D. vulgaris | x-ray diffraction | A, B | — | — |
| 1C7E | D95E hydroquinone flavodoxin mutant from D. vulgaris | x-ray diffraction | A, B | — | — |
| 1C7F | D95E oxidized flavodoxin mutant from D. vulgaris | x-ray diffraction | A, B | — | — |
| 1C7F | D95E oxidized flavodoxin mutant from D. vulgaris | x-ray diffraction | A, B | — | — |
| 1F4P | Y98W flavodoxin mutant 1.5A (D. vulgaris) | x-ray diffraction | A | — | — |
| 1F4P | Y98W flavodoxin mutant 1.5A (D. vulgaris) | x-ray diffraction | A | — | — |
| 1FX1 | A crystallographic structural study of the oxidation states of desulfovibrio vulgaris flavodoxin | x-ray diffraction | A | — | — |
| 1FX1 | A crystallographic structural study of the oxidation states of desulfovibrio vulgaris flavodoxin | x-ray diffraction | A | — | — |
| 1I1O | Room temperature crystal structure flavodoxin D. vulgaris mutant Y98H at 2.0 ang. resolution | x-ray diffraction | A | — | — |
| 1I1O | Room temperature crystal structure flavodoxin D. vulgaris mutant Y98H at 2.0 ang. resolution | x-ray diffraction | A | — | — |
| 1J8Q | Low Temperature (100K) Crystal Structure of Flavodoxin D. vulgaris Wild-type at 1.35 Angstrom… | x-ray diffraction | A | — | — |
| 1J8Q | Low temperature (100K) crystal structure of flavodoxin D. vulgaris wild-type at 1.35 ångström… | x-ray diffraction | A | — | — |
| 1J9E | Low Temperature (100K) Crystal Structure of Flavodoxin D. vulgaris S35C Mutant at 1.44 Angstrom… | x-ray diffraction | A | — | — |
| 1J9E | Low temperature (100K) crystal structure of flavodoxin D. vulgaris S35C mutant at 1.44 ångström… | x-ray diffraction | A | — | — |
| 1J9G | Low Temperature (100K) Crystal Structure of Flavodoxin D. vulgaris S64C Mutant, monomer oxidised… | x-ray diffraction | A | — | — |
| 1J9G | Low temperature (100K) crystal structure of flavodoxin D. vulgaris S64C mutant, monomer oxidised… | x-ray diffraction | A | — | — |
| 1WSB | Flavodoxin mutant- S64C | x-ray diffraction | A | — | — |
| 1WSB | Flavodoxin mutant- S64C | x-ray diffraction | A | — | — |
| 1WSW | Low Temperature (100K) Crystal Structure Of Flavodoxin Mutant S64C, dimer, semiqui state | x-ray diffraction | A | — | — |
| 1WSW | Low temperature (100K) crystal structure of flavodoxin mutant S64C, dimer, semiquinone state | x-ray diffraction | A | — | — |
| 1XT6 | S35C Flavodoxin Mutant in the semiqui state | x-ray diffraction | A | — | — |
| 1XT6 | S35C flavodoxin mutant in the semiquinone state | x-ray diffraction | A | — | — |
| 1XYV | Low Temperature (100K) Crystal Structure Of Flavodoxin Mutant S64C, monomer, semiqui state | x-ray diffraction | A | — | — |
| 1XYV | Low temperature (100K) crystal structure of flavodoxin mutant S64C, monomer, semiquinone state | x-ray diffraction | A | — | — |
| 1XYY | Low Temperature (100K) Crystal Structure Of Flavodoxin Mutant S64C, homodimer, oxidised state | x-ray diffraction | A | — | — |
| 1XYY | Low temperature (100K) crystal structure of flavodoxin mutant S64C, homodimer, oxidised state | x-ray diffraction | A | — | — |
| 2FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 2FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 3FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 3FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 4FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 4FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 5FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | FMN | 1 (best 0.49) |
| 5FX2 | Comparison of the crystal structures of a flavodoxin in its three oxidation states at cryogenic… | x-ray diffraction | A | — | — |
| 5TGZ | Crystal structure of the human cannabinoid receptor CB1 | x-ray diffraction | A | ZDG, FMN, OLA | — |
| 5V57 | 3.0A syn structure of the multi-domain human smoothened receptor in complex with TC114 | x-ray diffraction | A, B | 836, FMN | — |
| 5XR8 | Crystal structure of the human CB1 in complex with agonist AM841 | x-ray diffraction | A | FMN, 8D0, CLR | — |
| 5XRA | Crystal structure of the human CB1 in complex with agonist AM11542 | x-ray diffraction | A | FMN, 8D3, OLA, CLR | 5 (best 0.86) |
| 5XRA | Crystal structure of the human CB1 in complex with agonist AM11542 | x-ray diffraction | A | FMN, 8D3, OLA, CLR | — |
| 5YOB | Crystal structure of flavodoxin without engineered disulfide bond | x-ray diffraction | A | FMN | — |
| 5YOC | Crystal structure of flavodoxin with engineered disulfide bond C102- R125C | x-ray diffraction | A | FMN | — |
| 5YOE | Crystal Structure of flavodoxin with engineered disulfide bond A43C-L74C | x-ray diffraction | A | FMN | — |
| 5YOE | Crystal structure of flavodoxin with engineered disulfide bond A43C- L74C | x-ray diffraction | A | FMN | — |
| 5YOG | Crystal structure of flavodoxin with engineered disulfide bond N14C- C93 | x-ray diffraction | A | FMN, SO4 | — |
8 records more on the page itself.
Ligands
- FMN · Flavin mononucleotide · in 18 records
- CLR · Cholesterol · in 5 records
- OLA · Oleic acid · in 4 records
- 8D3 · (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol · in 2 records
- 9GF · 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol · in 2 records
- 836 · N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl) benzamide · in 1 record
- 8D0 · (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol · in 1 record
- 9ER · N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine · in 1 record
- EN6 · N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide · in 1 record
- H46 · ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide · in 1 record
- NA · Sodium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- VRJ · N-(tert-butylsulfonyl)-4-fluoro-2-{(3S,4R)-4-hydroxy-3-[(pyridin-2-yl)methyl]-3,4-dihydro-2H-1-benzopyran-7-yl}benzamide · in 1 record
- ZDG · 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate · in 1 record
Experiment against prediction
- 1C7F chain B against the predicted model P00323: TM-score 1.00, RMSD 0.31 Å
- 1C7F chain A against the predicted model P00323: TM-score 1.00, RMSD 0.32 Å
- 1C7F chain A against the predicted model P00323: TM-score 1.00, RMSD 0.32 Å
- 1J9G chain A against the predicted model P00323: TM-score 1.00, RMSD 0.32 Å
- 1J9G chain A against the predicted model P00323: TM-score 1.00, RMSD 0.32 Å
- 1WSB chain A against the predicted model P00323: TM-score 0.99, RMSD 0.33 Å
- 1WSB chain A against the predicted model P00323: TM-score 0.99, RMSD 0.33 Å
- 1J8Q chain A against the predicted model P00323: TM-score 0.99, RMSD 0.33 Å
- 1J8Q chain A against the predicted model P00323: TM-score 0.99, RMSD 0.33 Å
- 1AKV chain A against the predicted model P00323: TM-score 0.99, RMSD 0.33 Å
Elsewhere
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