MolNFT v1 · #189067 · protein
Crystal structure of omsk hemorrhagic fever virus NS5 mtase (with a gmp-ARG28 adduct and in complex with SAM)
7V1G · Core protein: “Crystal structure of omsk hemorrhagic fever virus NS5 mtase (with a gmp-ARG28 adduct and in complex with SAM)”. X-ray diffraction, 4 ligands (SAM, 5GP, GTP), 1 pocket (best druggability 0.67). MolNFT v1 #189067 on…
- PDB
- 7V1G
- Type
- protein
- Length
- 259 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Core protein
- EC
- 3.4.21.91, 3.6.1.15, 3.6.4.13
- UniProt
- C4TPE0
- Ligands
- SAM, 5GP, GTP, MG
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Core protein (EC 3.4.21.91, 3.6.1.15, 3.6.4.13) | protein | 259 | 39% helix, 19% strand | C4TPE0 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · chains A
- 5GP · Guanosine-5'-monophosphate · ligand · chains A
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- CIT · Citric acid · additive · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.67 | 0.77 | 48 | SAM |
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 7V1G · Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (with a GMP-Arg28 adduct and… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4TPE0
- Elsewhere: RCSB PDB 7V1G · PDBe 7V1G · UniProt C4TPE0
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