Sphingosine-1-phosphate receptor 1-gi complex bound to siponimod

Structure

electron microscopy · 4 distinct chains.

Ligands and binding sites

• J8C · 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl) phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid · ligand · chains R
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7TD4 · Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod · the same entry in another collection · chain R against R, TM-score 1.00
• P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• P21453 · AlphaFold monomer V2.0 prediction for sphingosine 1-phosphate receptor 1 (P21453) · a predicted model of the same protein · chain R against A, TM-score 0.93
• B2RSH2 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.64

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P62871
• Every structure of UniProt B2RSH2
• Every structure of UniProt P63212
• Every structure of UniProt P21453
• Elsewhere: RCSB PDB 7TD4 · PDBe 7TD4 · UniProt P62871 · UniProt B2RSH2 · UniProt P63212 · UniProt P21453