UniProt P21453
Sphingosine 1-phosphate receptor 1 (P21453)
Sphingosine 1-phosphate receptor 1 (UniProt P21453), EC 3.2.1.17: 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P21453
- Protein
- Sphingosine 1-phosphate receptor 1
- EC
- 3.2.1.17
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 26 · 6 records with a druggable one
Structures
17 records of P21453 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3V2W | Crystal Structure of a Lipid G protein-Coupled Receptor at 3.35A | x-ray diffraction | A | — | — |
| 3V2W | Crystal structure of a lipid G protein-coupled receptor at 3.35A | x-ray diffraction | A | — | — |
| 3V2Y | Crystal Structure of a Lipid G protein-Coupled Receptor at 2.80A | x-ray diffraction | A | — | — |
| 3V2Y | Crystal structure of a lipid G protein-coupled receptor at 2.80A | x-ray diffraction | A | — | — |
| 7EO2 | Cryo-EM of sphingosine 1-phosphate receptor 1 / gi complex bound to FTY720P | electron microscopy | A | J89 | — |
| 7EO4 | Cryo-EM of sphingosine 1-phosphate receptor 1 / gi complex bound to BAF312 | electron microscopy | A | J8C | — |
| 7TD3 | Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P | electron microscopy | R | S1P, NAG | — |
| 7TD3 | Sphingosine-1-phosphate receptor 1-gi complex bound to S1P | electron microscopy | R | S1P, NAG | — |
| 7TD4 | Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod | electron microscopy | R | NAG, J8C | — |
| 7TD4 | Sphingosine-1-phosphate receptor 1-gi complex bound to siponimod | electron microscopy | R | NAG, J8C | — |
| 7VIE | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P | electron microscopy | F | S1P | 4 (best 0.80) |
| 7VIF | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P | electron microscopy | F | J89 | 4 (best 0.76) |
| 7WF7 | Cryo-EM of Sphingosine 1-phosphate receptor 1 / Gi complex bound to S1P | electron microscopy | A | S1P | 5 (best 0.81) |
| 7WF7 | Cryo-EM of sphingosine 1-phosphate receptor 1 / gi complex bound to S1P | electron microscopy | A | S1P | — |
| 8G94 | Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi | electron microscopy | A | — | 6 (best 0.82) |
| 8YIC | SAR247799-bound S1PR1-Gi protein complex | electron microscopy | R | A1LYQ | 5 (best 0.81) |
| P21453 | AlphaFold monomer V2.0 prediction for sphingosine 1-phosphate receptor 1 (P21453) | predicted | A | — | 2 (best 0.80) |
Ligands
- S1P · (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- J8C · 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl) phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid · in 3 records
- J89 · (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol · in 2 records
- A1LYQ · Sar247799 · in 1 record
Experiment against prediction
- 7VIF chain F against the predicted model P21453: TM-score 0.94, RMSD 1.85 Å
- 7VIE chain F against the predicted model P21453: TM-score 0.94, RMSD 1.77 Å
- 7TD4 chain R against the predicted model P21453: TM-score 0.93, RMSD 2.01 Å
- 7TD4 chain R against the predicted model P21453: TM-score 0.93, RMSD 2.01 Å
- 7TD3 chain R against the predicted model P21453: TM-score 0.93, RMSD 2.05 Å
- 7TD3 chain R against the predicted model P21453: TM-score 0.93, RMSD 2.05 Å
- 7EO4 chain A against the predicted model P21453: TM-score 0.92, RMSD 1.97 Å
- 8G94 chain A against the predicted model P21453: TM-score 0.92, RMSD 2.11 Å
- 7EO2 chain A against the predicted model P21453: TM-score 0.92, RMSD 2.15 Å
- 7WF7 chain A against the predicted model P21453: TM-score 0.92, RMSD 2.07 Å
Elsewhere
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