MolNFT v1 · #188000 · protein
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2
7T6U · Guanine nucleotide-binding protein G(I) subunit alpha-1: “Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2”. Electron microscopy, 1 ligand (PLM), 14 pockets (best druggability…
- PDB
- 7T6U
- Type
- protein
- Length
- 1,152 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I) subunit alpha-1; Guanine nucleotide-binding…
- UniProt
- P63096, P54311, P63212, P25090
- Ligands
- PLM
- Pockets
- 14 · best druggability 0.82
Structure
electron microscopy · 6 distinct chains · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 219 | 46% helix, 18% strand | P63096 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 337 | 7% helix, 47% strand | P54311 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 54% helix, 0% strand | P63212 |
| E | B9-scfv | protein | 232 | 1% helix, 47% strand | — |
| L | Synthetic peptide | protein | 8 | 0% helix, 0% strand | — |
| R | N-formyl peptide receptor 2 | protein | 299 | 78% helix, 3% strand | P25090 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 2 copies · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 733 | 0.82 | 0.86 | 64 | empty |
| 2 | 1005 | 0.76 | 0.78 | 89 | empty |
| 3 | 62 | 0.68 | 0.95 | 15 | empty |
| 4 | 71 | 0.65 | 0.92 | 17 | empty |
| 5 | 358 | 0.64 | 0.79 | 59 | empty |
Interfaces
7 interfaces between chains.
- B–C · 2201 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1254 Ų buried · 16 hydrogen bonds · protein-protein
- A–R · 1143 Ų buried · 7 hydrogen bonds · protein-protein
- L–R · 869 Ų buried · 5 hydrogen bonds · protein-protein
- A–E · 611 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 1 modified (disulfide, nonstandard).
Compared structures
- 7T6U · Structure of the human FPR2-Gi complex with CGEN-855A · the same entry in another collection · chain R against R, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P25090 · AlphaFold monomer V2.0 prediction for N-formyl peptide receptor 2 (P25090) · a predicted model of the same protein · chain R against A, TM-score 0.93
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.81
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63096
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Every structure of UniProt P25090
- Elsewhere: RCSB PDB 7T6U · PDBe 7T6U · UniProt P63096 · UniProt P54311 · UniProt P63212 · UniProt P25090
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.