MolNFT v1 · #187959 · protein
Cryoem structure of the hcmv pentamer GH/GL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs 8I21 and 13H11
7T4S: “Cryoem structure of the hcmv pentamer GH/GL/UL128/UL130/UL131A in complex with NRP2 and neutralizing fabs…”. Electron microscopy, 2 ligands (NAG, CA). MolNFT v1 #187959 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7T4S
- Type
- protein
- Length
- 2,045 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- F5H9T3, Q71DN9, Q38LY2, Q38M07, Q8AZ45, O60462
- Ligands
- NAG, CA
Structure
electron microscopy · 10 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 624 | — | F5H9T3 |
| B | — | protein | 227 | — | Q71DN9 |
| C | — | protein | 112 | — | Q38LY2 |
| D | — | protein | 166 | — | Q38M07 |
| E | — | protein | 99 | — | Q8AZ45 |
| F | — | protein | 363 | — | O60462 |
| H | — | protein | 121 | — | — |
| J | — | protein | 121 | — | — |
| K | — | protein | 105 | — | — |
| I | — | protein | 107 | — | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A, D, I, C, E, F
- CA · Calcium ion · metal · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7T4S · CryoEM structure of the HCMV Pentamer gH/gL/UL128/UL130/UL131A in complex with NRP2 and… · the same entry in another collection · chain I against I, TM-score 1.00
- O60462 · AlphaFold monomer V2.0 prediction for neuropilin-2 (O60462) · a predicted model of the same protein · chain F against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F5H9T3
- Every structure of UniProt Q71DN9
- Every structure of UniProt Q38LY2
- Every structure of UniProt Q38M07
- Every structure of UniProt Q8AZ45
- Every structure of UniProt O60462
- Elsewhere: RCSB PDB 7T4S · PDBe 7T4S · UniProt F5H9T3 · UniProt Q71DN9 · UniProt Q38LY2 · UniProt Q38M07 · UniProt Q8AZ45 · UniProt O60462
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