MolNFT v1 · #270257 · protein
AlphaFold monomer V2.0 prediction for neuropilin-2 (O60462)
O60462: “AlphaFold monomer V2.0 prediction for neuropilin-2 (O60462)”. 7 pockets (best druggability 0.79). MolNFT v1 #270257 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O60462
- Type
- protein
- Length
- 931 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x56679c99FFEB4668142c4774dD42E1A30e9be883
- Molecule
- Neuropilin-2
- UniProt
- O60462
- Pockets
- 7 · best druggability 0.79
Structure
1 distinct chain · 7% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neuropilin-2 | protein | 931 | 7% helix, 37% strand | O60462 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.79 | 0.87 | 60 | empty |
| 2 | 504 | 0.76 | 0.84 | 66 | empty |
| 3 | 758 | 0.71 | 0.78 | 81 | empty |
| 4 | 188 | 0.52 | 0.78 | 19 | empty |
| 5 | 164 | 0.46 | 0.76 | 24 | empty |
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 2QQL · Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab · an experimental structure of the same protein · chain A against A, TM-score 0.59
- 2QQL · Neuropilin-2 A1A2B1B2 domains in complex with a semaphorin-blocking Fab · an experimental structure of the same protein · chain A against A, TM-score 0.59
- 2QQK · Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 2QQK · Neuropilin-2 A1A2B1B2 domains in complex with a semaphorin-blocking Fab · an experimental structure of the same protein · chain A against A, TM-score 0.57
- 2QQO · Crystal structure of the A2B1B2 domains from human neuropilin-2 · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 2QQO · Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2 · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 8IVW · Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment · an experimental structure of the same protein · chain A against J, TM-score 0.46
- 7M22 · Cryo-EM structure of the hcmv pentamer bound by human neuropilin 2 · an experimental structure of the same protein · chain A against N, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60462
- Elsewhere: UniProt O60462 · AlphaFold DB O60462
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