UniProt O60462
Neuropilin-2 (O60462)
Neuropilin-2 (UniProt O60462): 25 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60462
- Protein
- Neuropilin-2
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 21 · 2 records with a druggable one
Structures
26 records of O60462 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QQJ | Crystal Structure of the b1b2 Domains from Human Neuropilin-2 | x-ray diffraction | A | — | — |
| 2QQJ | Crystal structure of the B1B2 domains from human neuropilin-2 | x-ray diffraction | A | — | — |
| 2QQK | Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab | x-ray diffraction | A | — | — |
| 2QQK | Neuropilin-2 A1A2B1B2 domains in complex with a semaphorin-blocking Fab | x-ray diffraction | A | — | — |
| 2QQL | Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab | x-ray diffraction | A | — | — |
| 2QQL | Neuropilin-2 A1A2B1B2 domains in complex with a semaphorin-blocking Fab | x-ray diffraction | A | — | — |
| 2QQO | Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2 | x-ray diffraction | A, B | — | — |
| 2QQO | Crystal structure of the A2B1B2 domains from human neuropilin-2 | x-ray diffraction | A, B | — | — |
| 4QDQ | Physical basis for Nrp2 ligand binding | x-ray diffraction | A, B | — | — |
| 4QDQ | Physical basis for NRP2 ligand binding | x-ray diffraction | A, B | — | — |
| 4QDR | Physical basis for Nrp2 ligand binding | x-ray diffraction | A | — | — |
| 4QDR | Physical basis for NRP2 ligand binding | x-ray diffraction | A | — | — |
| 4QDS | Physical basis for Nrp2 ligand binding | x-ray diffraction | A, B | — | — |
| 4QDS | Physical basis for NRP2 ligand binding | x-ray diffraction | A, B | — | — |
| 5DN2 | Human NRP2 b1 domain in complex with the peptide corresponding to the C-terminus of VEGF-A | x-ray diffraction | A, B, C, D | — | — |
| 5DN2 | Human NRP2 B1 domain in complex with the peptide corresponding to the C-terminus of VEGF-a | x-ray diffraction | A, B, C, D | — | — |
| 5DQ0 | Structure of human neuropilin-2 b1 domain with novel and unique zinc binding site | x-ray diffraction | A | ZN, CL | — |
| 5DQ0 | Structure of human neuropilin-2 B1 domain with novel and unique zinc binding site | x-ray diffraction | A | — | — |
| 6GH8 | Crystal structure of GP1 domain of lujo virus in complex with the first cub domain of neuropilin-2 | x-ray diffraction | A, C | NAG, CA | — |
| 6TDB | Neuropilin2-b1 domain in a complex with the C-terminal VEGFB167 peptide | x-ray diffraction | A, B, C, D | ACE | — |
| 6TDB | NEUROPILIN2-B1 domain in a complex with the C-terminal VEGFB167 peptide | x-ray diffraction | A, B, C, D | ACE | — |
| 6TJT | NEUROPILIN2-B1 domain in a complex with the C-terminal vegfc peptide | x-ray diffraction | A, B | SO4 | — |
| 7M22 | Cryo-EM structure of the hcmv pentamer bound by human neuropilin 2 | electron microscopy | N | CA, NAG | — |
| 7T4S | Cryoem structure of the hcmv pentamer GH/GL/UL128/UL130/UL131A in complex with NRP2 and… | electron microscopy | F | NAG, CA | — |
| 8IVW | Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment | x-ray diffraction | A, D, G, J | — | 14 (best 0.71) |
| O60462 | AlphaFold monomer V2.0 prediction for neuropilin-2 (O60462) | predicted | A | — | 7 (best 0.79) |
Ligands
Experiment against prediction
- 5DN2 chain A against the predicted model O60462: TM-score 0.99, RMSD 0.36 Å
- 5DN2 chain A against the predicted model O60462: TM-score 0.99, RMSD 0.36 Å
- 8IVW chain D against the predicted model O60462: TM-score 0.99, RMSD 0.59 Å
- 7T4S chain F against the predicted model O60462: TM-score 0.99, RMSD 0.57 Å
- 2QQO chain B against the predicted model O60462: TM-score 0.99, RMSD 0.65 Å
- 2QQO chain B against the predicted model O60462: TM-score 0.99, RMSD 0.65 Å
- 8IVW chain A against the predicted model O60462: TM-score 0.99, RMSD 0.73 Å
- 8IVW chain G against the predicted model O60462: TM-score 0.99, RMSD 0.64 Å
- 8IVW chain J against the predicted model O60462: TM-score 0.99, RMSD 0.79 Å
- 2QQO chain A against the predicted model O60462: TM-score 0.99, RMSD 0.75 Å
Elsewhere
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