MolNFT v1 · #186966 · protein
AP2 bound to the apa domain of sgip and heparin; partial signal subtraction and symmetry expansion
7RWC · Ap-2 complex subunit alpha-2: “AP2 bound to the apa domain of sgip and heparin; partial signal subtraction and symmetry expansion”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #186966 on GenesisL1: 3D…
- PDB
- 7RWC
- Type
- protein
- Length
- 1,713 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit alpha-2; Ap-2 complex subunit beta; Ap-2 complex subunit mu; Ap-2…
- UniProt
- P17427, Q9DBG3, P84091, P62743
- Pockets
- 20 · best druggability 0.77
Structure
electron microscopy · 5 distinct chains · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit alpha-2 | protein | 613 | 69% helix, 1% strand | P17427 |
| B | Ap-2 complex subunit beta | protein | 557 | 64% helix, 0% strand | Q9DBG3 |
| M | Ap-2 complex subunit mu | protein | 393 | 15% helix, 38% strand | P84091 |
| S | Ap-2 complex subunit sigma | protein | 142 | 43% helix, 23% strand | P62743 |
| P | SH3-containing GRB2-like protein 3-interacting protein 1 | protein | 8 | 0% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 570 | 0.77 | 0.83 | 68 | empty |
| 2 | 452 | 0.75 | 0.84 | 82 | empty |
| 3 | 1065 | 0.72 | 0.76 | 107 | empty |
| 4 | 617 | 0.72 | 0.79 | 65 | empty |
| 5 | 69 | 0.67 | 0.94 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–S · 2441 Ų buried · 26 hydrogen bonds · protein-protein
- B–M · 2019 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1827 Ų buried · 18 hydrogen bonds · protein-protein
- A–M · 443 Ų buried · 0 hydrogen bonds · protein-protein
- B–P · 410 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7RWC · AP2 bound to the APA domain of SGIP and heparin; partial signal subtraction and symmetry… · the same entry in another collection · chain P against P, TM-score 1.00
- P62743 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit sigma (P62743) · a predicted model of the same protein · chain S against A, TM-score 0.97
- P17427 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit alpha-2 (P17427) · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q9DBG3 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit beta (Q9DBG3) · a predicted model of the same protein · chain B against A, TM-score 0.85
- P84091 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84091) · a predicted model of the same protein · chain M against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17427
- Every structure of UniProt Q9DBG3
- Every structure of UniProt P84091
- Every structure of UniProt P62743
- Elsewhere: RCSB PDB 7RWC · PDBe 7RWC · UniProt P17427 · UniProt Q9DBG3 · UniProt P84091 · UniProt P62743
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