UniProt P17427
AP-2 complex subunit alpha-2 (P17427)
AP-2 complex subunit alpha-2 (UniProt P17427): 32 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P17427
- Protein
- AP-2 complex subunit alpha-2
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 11 · 1 record with a druggable one
Structures
33 records of P17427 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B9K | Alpha-adaptin appendage domain, from clathrin adaptor AP2 | x-ray diffraction | A | — | — |
| 1B9K | Alpha-adaptin appendage domain, from clathrin adaptor AP2 | x-ray diffraction | A | — | — |
| 1KY6 | Ap-2 clathrin adaptor alpha-appendage in complex with epsin dpw peptide | x-ray diffraction | A | — | — |
| 1KY6 | Ap-2 clathrin adaptor alpha-appendage in complex with epsin dpw peptide | x-ray diffraction | A | — | — |
| 1KY7 | The ap-2 clathrin adaptor alpha-appendage in complex with amphiphysin fxdxf | x-ray diffraction | A | — | — |
| 1KY7 | The ap-2 clathrin adaptor alpha-appendage in complex with amphiphysin fxdxf | x-ray diffraction | A | — | — |
| 1KYD | Ap-2 clathrin adaptor alpha-appendage in complex with epsin dpw peptide | x-ray diffraction | A | — | — |
| 1KYD | Ap-2 clathrin adaptor alpha-appendage in complex with epsin dpw peptide | x-ray diffraction | A | — | — |
| 1KYF | Ap-2 clathrin adaptor alpha-appendage in complex with EPS15 dpf peptide | x-ray diffraction | A | — | — |
| 1KYF | Ap-2 clathrin adaptor alpha-appendage in complex with EPS15 dpf peptide | x-ray diffraction | A | — | — |
| 1KYU | Ap-2 clathrin adaptor alpha-appendage in complex with EPS15 dpf peptide | x-ray diffraction | A | — | — |
| 1KYU | Ap-2 clathrin adaptor alpha-appendage in complex with EPS15 dpf peptide | x-ray diffraction | A | — | — |
| 1QTP | Crystal structure of the ap-2 clathrin adaptor alpha-appendage | x-ray diffraction | A | — | — |
| 1QTP | Crystal structure of the ap-2 clathrin adaptor alpha- appendage | x-ray diffraction | A | — | — |
| 1QTS | Crystal structure of the ap-2 clathrin adaptor alpha-appendage | x-ray diffraction | A | — | — |
| 1QTS | Crystal structure of the ap-2 clathrin adaptor alpha- appendage | x-ray diffraction | A | — | — |
| 1W80 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2… | x-ray diffraction | A | — | — |
| 1W80 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2… | x-ray diffraction | A | — | — |
| 2JKR | AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE | x-ray diffraction | A, L | — | — |
| 2JKR | AP2 clathrin adaptor core with dileucine peptide rm( PHOSPHOS)QIKRLLSE | x-ray diffraction | A, L | — | — |
| 2JKT | AP2 CLATHRIN ADAPTOR CORE with CD4 Dileucine peptide RM(phosphoS) EIKRLLSE Q to E mutant | x-ray diffraction | A, L | — | — |
| 2JKT | AP2 clathrin adaptor core with CD4 dileucine peptide rm( PHOSPHOS)EIKRLLSE Q to E mutant | x-ray diffraction | A, L | — | — |
| 2VJ0 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex… | x-ray diffraction | A | — | — |
| 2VJ0 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex… | x-ray diffraction | A | — | — |
| 7OHI | FCHO1-peptide-AP2 alpha ear complex | x-ray diffraction | A | SO4 | 1 (best 0.29) |
| 7OHI | FCHO1-peptide-AP2 alpha ear complex | x-ray diffraction | A | SO4 | — |
| 7RW8 | AP2 bound to heparin in the closed conformation | electron microscopy | A | — | — |
| 7RW9 | AP2 bound to heparin in the bowl conformation | electron microscopy | A | — | — |
| 7RWA | AP2 bound to heparin and TGN38 tyrosine cargo peptide | electron microscopy | A, a | — | — |
| 7RWB | AP2 bound to the APA domain of SGIP in the presence of heparin | electron microscopy | A, a | — | 10 (best 0.74) |
| 7RWB | AP2 bound to the apa domain of sgip in the presence of heparin | electron microscopy | A, a | — | — |
| 7RWC | AP2 bound to the apa domain of sgip and heparin; partial signal subtraction and symmetry expansion | electron microscopy | A | — | — |
| P17427 | AlphaFold monomer V2.0 prediction for ap-2 complex subunit alpha-2 (P17427) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 1B9K chain A against the predicted model P17427: TM-score 0.99, RMSD 0.66 Å
- 1B9K chain A against the predicted model P17427: TM-score 0.99, RMSD 0.66 Å
- 1W80 chain A against the predicted model P17427: TM-score 0.97, RMSD 1.17 Å
- 1W80 chain A against the predicted model P17427: TM-score 0.97, RMSD 1.17 Å
- 2VJ0 chain A against the predicted model P17427: TM-score 0.97, RMSD 1.11 Å
- 2VJ0 chain A against the predicted model P17427: TM-score 0.97, RMSD 1.11 Å
- 7OHI chain A against the predicted model P17427: TM-score 0.96, RMSD 1.06 Å
- 7OHI chain A against the predicted model P17427: TM-score 0.96, RMSD 1.06 Å
- 1QTP chain A against the predicted model P17427: TM-score 0.96, RMSD 1.07 Å
- 1QTP chain A against the predicted model P17427: TM-score 0.96, RMSD 1.07 Å
Elsewhere
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