UniProt P62743
AP-2 complex subunit sigma (P62743)
AP-2 complex subunit sigma (UniProt P62743): 26 experimental structures and 1 predicted model on GenesisL1, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P62743
- Protein
- AP-2 complex subunit sigma
- Experimental structures
- 26
- Predicted models
- 1
- Pockets
- 13 · 2 records with a druggable one
Structures
27 records of P62743 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JKR | AP2 CLATHRIN ADAPTOR CORE with Dileucine peptide RM(phosphoS)QIKRLLSE | x-ray diffraction | I, S | — | — |
| 2JKR | AP2 clathrin adaptor core with dileucine peptide rm( PHOSPHOS)QIKRLLSE | x-ray diffraction | I, S | — | — |
| 2JKT | AP2 CLATHRIN ADAPTOR CORE with CD4 Dileucine peptide RM(phosphoS) EIKRLLSE Q to E mutant | x-ray diffraction | I, S | — | — |
| 2JKT | AP2 clathrin adaptor core with CD4 dileucine peptide rm( PHOSPHOS)EIKRLLSE Q to E mutant | x-ray diffraction | I, S | — | — |
| 2VGL | AP2 clathrin adaptor core | x-ray diffraction | S | — | — |
| 2VGL | AP2 clathrin adaptor core | x-ray diffraction | S | — | — |
| 2XA7 | AP2 clathrin adaptor core in active complex with cargo peptides | x-ray diffraction | S | — | — |
| 2XA7 | AP2 clathrin adaptor core in active complex with cargo peptides | x-ray diffraction | S | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | S | — | — |
| 4UQI | AP2 controls clathrin polymerization with a membrane-activated switch | x-ray diffraction | S | — | — |
| 6QH5 | AP2 clathrin adaptor MU2T156-phosphorylated core in closed conformation | x-ray diffraction | S | — | — |
| 6QH6 | AP2 clathrin adaptor core with two cargo peptides in open+ conformation | x-ray diffraction | S | — | — |
| 6QH7 | AP2 clathrin adaptor MU2T156-phosphorylated core with two cargo peptides in open+ conformation | x-ray diffraction | S | — | — |
| 6YAE | AP2 core in physiological buffer | electron microscopy | S | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | S | — | — |
| 6YAF | AP2 on a membrane containing tyrosine-based cargo peptide | electron microscopy | S | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | S | — | — |
| 6YAH | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo… | electron microscopy | S | — | — |
| 7OHO | Crystal structure of AP2 FCHO2 chimera | x-ray diffraction | SSS | — | 7 (best 0.85) |
| 7RW8 | AP2 bound to heparin in the closed conformation | electron microscopy | S | — | — |
| 7RW9 | AP2 bound to heparin in the bowl conformation | electron microscopy | S | — | — |
| 7RWA | AP2 bound to heparin and TGN38 tyrosine cargo peptide | electron microscopy | S, s | — | — |
| 7RWB | AP2 bound to the APA domain of SGIP in the presence of heparin | electron microscopy | S, s | — | 6 (best 0.74) |
| 7RWB | AP2 bound to the apa domain of sgip in the presence of heparin | electron microscopy | S, s | — | — |
| 7RWC | AP2 bound to the apa domain of sgip and heparin; partial signal subtraction and symmetry expansion | electron microscopy | S | — | — |
| 7Z5C | Chimera of AP2 with FCHO2 linker domain as a fusion on CMU2 subunit | electron microscopy | S | — | — |
| P62743 | AlphaFold monomer V2.0 prediction for ap-2 complex subunit sigma (P62743) | predicted | A | — | — |
Experiment against prediction
- 2VGL chain S against the predicted model P62743: TM-score 0.98, RMSD 0.57 Å
- 2VGL chain S against the predicted model P62743: TM-score 0.98, RMSD 0.57 Å
- 6QH5 chain S against the predicted model P62743: TM-score 0.98, RMSD 0.58 Å
- 7OHO chain SSS against the predicted model P62743: TM-score 0.98, RMSD 0.58 Å
- 4UQI chain S against the predicted model P62743: TM-score 0.98, RMSD 0.58 Å
- 4UQI chain S against the predicted model P62743: TM-score 0.98, RMSD 0.58 Å
- 6QH7 chain S against the predicted model P62743: TM-score 0.98, RMSD 0.63 Å
- 7RW8 chain S against the predicted model P62743: TM-score 0.98, RMSD 0.63 Å
- 2JKT chain I against the predicted model P62743: TM-score 0.98, RMSD 0.63 Å
- 2JKT chain I against the predicted model P62743: TM-score 0.98, RMSD 0.63 Å
Elsewhere
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