MolNFT v1 · #186695 · protein
SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with MINIGS/Q70
7RMI: “SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with MINIGS/Q70”. Electron microscopy, 1 ligand (NH2). MolNFT v1 #186695 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RMI
- Type
- protein
- Length
- 960 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63092, P25103, P62873, P59768
- Ligands
- NH2
Structure
electron microscopy · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 194 | — | P63092 |
| R | — | protein | 285 | — | P25103 |
| S | — | protein | 6 | — | — |
| B | — | protein | 322 | — | P62873 |
| G | — | protein | 38 | — | P59768 |
| N | — | protein | 115 | — | — |
Ligands and binding sites
- NH2 · Amino group · ion · chains R, S
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RMI · SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with… · the same entry in another collection · chain N against N, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P25103 · AlphaFold monomer V2.0 prediction for substance-P receptor (P25103) · a predicted model of the same protein · chain R against A, TM-score 0.92
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P25103
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7RMI · PDBe 7RMI · UniProt P63092 · UniProt P25103 · UniProt P62873 · UniProt P59768
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