MolNFT v1 · #186550 · protein
Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-diltiazem- blocked open state
7RHJ: “Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-diltiazem- blocked open state”. Electron microscopy, 2 ligands (PCG, 5H0). MolNFT v1 #186550 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RHJ
- Type
- protein
- Length
- 1,783 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P29973, Q14028
- Ligands
- PCG, 5H0
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | — | protein | 450 | — | P29973 |
| B | — | protein | 433 | — | Q14028 |
Ligands and binding sites
- PCG · Cyclic guanosine monophosphate · ligand · 4 copies · chains A, B, C, D
- 5H0 · (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate · ligand · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RHJ · Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state · the same entry in another collection · chain D against D, TM-score 1.00
- P29973 · AlphaFold monomer V2.0 prediction for cgmp-gated cation channel alpha-1 (P29973) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q14028 · AlphaFold monomer V2.0 prediction for cyclic nucleotide-gated cation channel beta-1… · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29973
- Every structure of UniProt Q14028
- Elsewhere: RCSB PDB 7RHJ · PDBe 7RHJ · UniProt P29973 · UniProt Q14028
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