UniProt P29973
cGMP-gated cation channel alpha-1 (P29973)
cGMP-gated cation channel alpha-1 (UniProt P29973): 18 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P29973
- Protein
- cGMP-gated cation channel alpha-1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 60 · 3 records with a druggable one
Structures
19 records of P29973 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7LFT | Cryo-EM structure of human apo CNGA1 channel in K+/CA2+ | electron microscopy | A, B, C, D | CLR, CPL, K | — |
| 7LFW | Cryo-EM structure of human cgmp-bound open CNGA1 channel in K+/CA2+ | electron microscopy | A, B, C, D | PCG, CA | — |
| 7LFX | Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+ | electron microscopy | A, B, C, D | PCG, CA | — |
| 7LFX | Cryo-EM structure of human cgmp-bound open CNGA1 channel in NA+/CA2+ | electron microscopy | A, B, C, D | PCG, CA | — |
| 7LFY | Cryo-EM structure of human cgmp-bound open CNGA1 channel in na+ | electron microscopy | A, B, C, D | PCG, NA | — |
| 7LG1 | Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+ | electron microscopy | A, B, C, D | PCG, CA | 20 (best 0.84) |
| 7LG1 | Cryo-EM structure of human cgmp-bound CNGA1_E365Q channel in NA+/CA2+ | electron microscopy | A, B, C, D | PCG, CA | — |
| 7RH9 | Cryo-EM structure of human rod CNGA1/B1 channel in apo state | electron microscopy | C, A, D | — | 20 (best 0.74) |
| 7RH9 | Cryo-EM structure of human rod CNGA1/B1 channel in apo state | electron microscopy | C, A, D | — | — |
| 7RHG | Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | electron microscopy | C, A, D | CMP | — |
| 7RHG | Cryo-EM structure of human rod CNGA1/B1 channel in camp-bound state | electron microscopy | C, A, D | CMP | — |
| 7RHH | Cryo-EM structure of human rod CNGA1/B1 channel in cgmp-bound openi state | electron microscopy | A, C, D | PCG | — |
| 7RHI | Cryo-EM structure of human rod CNGA1/B1 channel in cgmp-bound openii state | electron microscopy | A, C, D | PCG | — |
| 7RHJ | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state | electron microscopy | A, C, D | PCG, 5H0 | — |
| 7RHJ | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-diltiazem- blocked open state | electron microscopy | A, C, D | PCG, 5H0 | — |
| 7RHK | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state | electron microscopy | C, A, D | PCG, 5H0 | 20 (best 0.83) |
| 7RHK | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-diltiazem- trapped closed state | electron microscopy | C, A, D | PCG, 5H0 | — |
| 7RHL | Cryo-EM structure of human rod apo CNGA1/B1 channel with clz coiled coil | electron microscopy | C, A, D | — | — |
| P29973 | AlphaFold monomer V2.0 prediction for cgmp-gated cation channel alpha-1 (P29973) | predicted | A | — | — |
Ligands
- PCG · Cyclic guanosine monophosphate · in 12 records
- CA · Calcium ion · in 5 records
- 5H0 · (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate · in 4 records
- CMP · Adenosine-3',5'-cyclic-monophosphate · in 2 records
- CLR · Cholesterol · in 1 record
- CPL · 1-palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine · in 1 record
- K · Potassium ion · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 7RHI chain A against the predicted model P29973: TM-score 0.94, RMSD 1.91 Å
- 7LFX chain C against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFX chain C against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFW chain C against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFX chain D against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFX chain D against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFY chain C against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFW chain D against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFY chain D against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
- 7LFY chain B against the predicted model P29973: TM-score 0.94, RMSD 2.01 Å
Elsewhere
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