MolNFT v1 · #186012 · protein
The PDZ domain of LRRC7 fused with ANXA2
7QQM · Leucine-rich repeat-containing protein 7,ANNEXIN A2: “The PDZ domain of LRRC7 fused with ANXA2”. X-ray diffraction, 1 ligand (CA), 5 pockets (best druggability 0.62). MolNFT v1 #186012 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7QQM
- Type
- protein
- Length
- 413 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat-containing protein 7,ANNEXIN A2
- UniProt
- Q96NW7, P07355
- Ligands
- CA
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 59% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat-containing protein 7,ANNEXIN A2 | protein | 413 | 59% helix, 8% strand | Q96NW7, P07355 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.62 | 0.86 | 24 | empty |
| 2 | 98 | 0.53 | 0.84 | 21 | GOL |
| 3 | 120 | 0.50 | 0.80 | 29 | GOL |
| 4 | 61 | 0.40 | 0.80 | 16 | empty |
| 5 | 53 | 0.27 | 0.74 | 13 | empty |
Compared structures
- 7QQM · The PDZ domain of LRRC7 fused with ANXA2 · the same entry in another collection · chain A against A, TM-score 1.00
- P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 0.75
- Q96NW7 · AlphaFold monomer V2.0 prediction for leucine-rich repeat-containing protein 7 (Q96NW7) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96NW7
- Every structure of UniProt P07355
- Elsewhere: RCSB PDB 7QQM · PDBe 7QQM · UniProt Q96NW7 · UniProt P07355
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