MolNFT v1 · #185963 · protein
Cryo-EM structure of human full-length BETA3DELTA GABA(A)R in complex with histamine and nanobody NB25
7QN8: “Cryo-EM structure of human full-length BETA3DELTA GABA(A)R in complex with histamine and nanobody NB25”. Electron microscopy, 4 ligands (HSM, NAG, MAN). MolNFT v1 #185963 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7QN8
- Type
- protein
- Length
- 1,992 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P28472, O14764
- Ligands
- HSM, NAG, MAN, BMA
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 327 | — | P28472 |
| E | — | protein | 321 | — | O14764 |
| K, L, M | — | protein | 121 | — | — |
Ligands and binding sites
- HSM · Histamine · ligand · 3 copies · chains A, B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 17 copies · chains A, B, K, C, L, D, M, E
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains A, K, L, M
- BMA · beta-D-mannopyranose · sugar · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7QN8 · Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and… · the same entry in another collection · chain M against M, TM-score 1.00
- P28472 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit beta-3… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28472
- Every structure of UniProt O14764
- Elsewhere: RCSB PDB 7QN8 · PDBe 7QN8 · UniProt P28472 · UniProt O14764
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