MolNFT v1 · #185842 · protein
Tentative model of the human insulin receptor ectodomain bound by three insulin
7QID: “Tentative model of the human insulin receptor ectodomain bound by three insulin”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #185842 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7QID
- Type
- protein
- Length
- 1,979 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Isoform short of insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P06213, P01308
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 4 distinct chains · 9% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin receptor (EC 2.7.10.1) | protein | 719 | 9% helix, 22% strand | P06213 |
| B, D | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 194 | 4% helix, 12% strand | — |
| E, K, I | Insulin | protein | 21 | 19% helix, 0% strand | P01308 |
| F, L, J | Insulin | protein | 30 | 37% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.84 | 0.94 | 36 | empty |
| 2 | 1133 | 0.80 | 0.82 | 106 | empty |
| 3 | 198 | 0.80 | 0.93 | 44 | empty |
| 4 | 125 | 0.79 | 0.96 | 23 | empty |
| 5 | 758 | 0.77 | 0.81 | 53 | empty |
Interfaces
17 interfaces between chains.
- C–D · 3016 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 2591 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2519 Ų buried · 16 hydrogen bonds · protein-protein
- C–L · 839 Ų buried · 2 hydrogen bonds · protein-protein
- I–J · 698 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 49 disulfide (disulfide).
Compared structures
- 7QID · tentative model of the human insulin receptor ectodomain bound by three insulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7QID · PDBe 7QID · UniProt P06213 · UniProt P01308
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