Research workbench
Tentative model of the human insulin receptor ectodomain bound by three insulin
Analyse Tentative model of the human insulin receptor ectodomain bound by three insulin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QID
- Type
- protein
- Length
- 1,979 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Isoform short of insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P06213, P01308
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 4 distinct chains · 9% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin receptor (EC 2.7.10.1) | protein | 719 | 9% helix, 22% strand | P06213 |
| B, D | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 194 | 4% helix, 12% strand | — |
| E, K, I | Insulin | protein | 21 | 19% helix, 0% strand | P01308 |
| F, L, J | Insulin | protein | 30 | 37% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 281 | 0.84 | 0.94 | 36 | empty |
| 2 | 1133 | 0.80 | 0.82 | 106 | empty |
| 3 | 198 | 0.80 | 0.93 | 44 | empty |
| 4 | 125 | 0.79 | 0.96 | 23 | empty |
| 5 | 758 | 0.77 | 0.81 | 53 | empty |
Interfaces
17 interfaces between chains.
- C–D · 3016 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 2591 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2519 Ų buried · 16 hydrogen bonds · protein-protein
- C–L · 839 Ų buried · 2 hydrogen bonds · protein-protein
- I–J · 698 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 49 disulfide (disulfide).
Compared structures
- 7QID · tentative model of the human insulin receptor ectodomain bound by three insulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7QID · PDBe 7QID · UniProt P06213 · UniProt P01308
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