Quaternary complex of human WDR5 and PVHL:ELONGINC:ELONGINB bound to protac homer

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• 8KH · N-[5-[4-[[5-[[(2S)-3,3-dimethyl-1-[(2S,4R)-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-5-oxidanylidene-pentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1H-pyridine-3-carboxamide · ligand · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7Q2J · Quaternary Complex of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC Homer · the same entry in another collection · chain A against A, TM-score 1.00
• Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain B against A, TM-score 0.97
• Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q15370
• Every structure of UniProt Q15369
• Every structure of UniProt P40337
• Every structure of UniProt P61964
• Elsewhere: RCSB PDB 7Q2J · PDBe 7Q2J · UniProt Q15370 · UniProt Q15369 · UniProt P40337 · UniProt P61964