MolNFT v1 · #185460 · protein
Structure of U5 snrnp assembly and recycling factor TSSC4 in complex with BRR2 and JAB1 domain of PRPF8
7PX3 · U5 small nuclear ribonucleoprotein 200 kda helicase: “Structure of U5 snrnp assembly and recycling factor TSSC4 in complex with BRR2 and JAB1 domain of PRPF8”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 7PX3
- Type
- protein
- Length
- 2,041 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U5 small nuclear ribonucleoprotein 200 kda helicase; Pre-mRNA-processing-splicing factor…
- EC
- 3.6.4.13
- UniProt
- O75643, Q6P2Q9, Q9Y5U2
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | U5 small nuclear ribonucleoprotein 200 kda helicase (EC 3.6.4.13) | protein | 1725 | 44% helix, 18% strand | O75643 |
| J | Pre-mRNA-processing-splicing factor 8 | protein | 250 | 26% helix, 28% strand | Q6P2Q9 |
| T | Protein TSSC4 | protein | 66 | 6% helix, 8% strand | Q9Y5U2 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1197 | 0.85 | 0.86 | 115 | empty |
| 2 | 1126 | 0.84 | 0.85 | 86 | empty |
| 3 | 479 | 0.78 | 0.85 | 46 | empty |
| 4 | 87 | 0.74 | 0.96 | 26 | empty |
| 5 | 617 | 0.71 | 0.79 | 43 | empty |
Interfaces
3 interfaces between chains.
- B–T · 2396 Ų buried · 25 hydrogen bonds · protein-protein
- B–J · 1736 Ų buried · 18 hydrogen bonds · protein-protein
- J–T · 765 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7PX3 · Structure of U5 snRNP assembly and recycling factor TSSC4 in complex with BRR2 and Jab1… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9Y5U2 · AlphaFold monomer V2.0 prediction for protein TSSC4 (Q9Y5U2) · a predicted model of the same protein · chain T against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75643
- Every structure of UniProt Q6P2Q9
- Every structure of UniProt Q9Y5U2
- Elsewhere: RCSB PDB 7PX3 · PDBe 7PX3 · UniProt O75643 · UniProt Q6P2Q9 · UniProt Q9Y5U2
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