Research workbench
Structure of U5 snrnp assembly and recycling factor TSSC4 in complex with BRR2 and JAB1 domain of PRPF8
Analyse Structure of U5 snrnp assembly and recycling factor TSSC4 in complex with BRR2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7PX3
- Type
- protein
- Length
- 2,041 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U5 small nuclear ribonucleoprotein 200 kda helicase; Pre-mRNA-processing-splicing factor…
- EC
- 3.6.4.13
- UniProt
- O75643, Q6P2Q9, Q9Y5U2
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | U5 small nuclear ribonucleoprotein 200 kda helicase (EC 3.6.4.13) | protein | 1725 | 44% helix, 18% strand | O75643 |
| J | Pre-mRNA-processing-splicing factor 8 | protein | 250 | 26% helix, 28% strand | Q6P2Q9 |
| T | Protein TSSC4 | protein | 66 | 6% helix, 8% strand | Q9Y5U2 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1197 | 0.85 | 0.86 | 115 | empty |
| 2 | 1126 | 0.84 | 0.85 | 86 | empty |
| 3 | 479 | 0.78 | 0.85 | 46 | empty |
| 4 | 87 | 0.74 | 0.96 | 26 | empty |
| 5 | 617 | 0.71 | 0.79 | 43 | empty |
Interfaces
3 interfaces between chains.
- B–T · 2396 Ų buried · 25 hydrogen bonds · protein-protein
- B–J · 1736 Ų buried · 18 hydrogen bonds · protein-protein
- J–T · 765 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7PX3 · Structure of U5 snRNP assembly and recycling factor TSSC4 in complex with BRR2 and Jab1… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9Y5U2 · AlphaFold monomer V2.0 prediction for protein TSSC4 (Q9Y5U2) · a predicted model of the same protein · chain T against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75643
- Every structure of UniProt Q6P2Q9
- Every structure of UniProt Q9Y5U2
- Elsewhere: RCSB PDB 7PX3 · PDBe 7PX3 · UniProt O75643 · UniProt Q6P2Q9 · UniProt Q9Y5U2
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