Structure of an inhibited GRK2-G-beta and G-gamma complex

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• 8DS · 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide · ligand · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• 1PE · Pentaethylene glycol · additive · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7PWD · Structure of an inhibited GRK2-G-beta and G-gamma complex · the same entry in another collection · chain A against A, TM-score 1.00
• P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P25098 · AlphaFold monomer V2.0 prediction for beta-adrenergic receptor kinase 1 (P25098) · a predicted model of the same protein · chain A against A, TM-score 0.99
• P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.61

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P25098
• Every structure of UniProt P62871
• Every structure of UniProt P63212
• Elsewhere: RCSB PDB 7PWD · PDBe 7PWD · UniProt P25098 · UniProt P62871 · UniProt P63212