Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C- terminus, bound to a SMG1 inhibitor

Structure

electron microscopy · 3 distinct chains.

Ligands and binding sites

• IHP · Inositol hexakisphosphate · ligand · chains A
• 88C · 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl) phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea · ligand · chains A
• ATP · Adenosine-5'-triphosphate · ligand · chains C
• MG · Magnesium ion · metal · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7PW5 · Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1… · the same entry in another collection · chain C against C, TM-score 1.00
• 7PW4 · Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor · an experimental structure of the same protein · chain C against C, TM-score 1.00
• 7PW4 · Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor · an experimental structure of the same protein · chain C against C, TM-score 1.00
• 7PW7 · Human SMG1-9 kinase complex bound to a SMG1 inhibitor · an experimental structure of the same protein · chain A against A, TM-score 1.00
• 7PW7 · Human SMG1-9 kinase complex bound to a SMG1 inhibitor · an experimental structure of the same protein · chain A against A, TM-score 1.00
• 7PW8 · Human SMG1-8-9 kinase complex bound to AMPPNP · an experimental structure of the same protein · chain A against A, TM-score 1.00
• 7PW8 · Human SMG1-8-9 kinase complex bound to amppnp · an experimental structure of the same protein · chain A against A, TM-score 1.00
• 6Z3R · Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ · an experimental structure of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q96Q15
• Every structure of UniProt Q8ND04
• Every structure of UniProt Q9H0W8
• Elsewhere: RCSB PDB 7PW5 · PDBe 7PW5 · UniProt Q96Q15 · AlphaFold DB Q96Q15 · UniProt Q8ND04 · AlphaFold DB Q8ND04 · UniProt Q9H0W8 · AlphaFold DB Q9H0W8