UniProt Q8ND04
Protein SMG8 (Q8ND04)
Protein SMG8 (UniProt Q8ND04): 11 experimental structures and 2 predicted models on GenesisL1, 18 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8ND04
- Protein
- Protein SMG8
- Experimental structures
- 11
- Predicted models
- 2
- Pockets
- 18 · 5 records with a druggable one
Structures
13 records of Q8ND04 in the MolNFT archive: 11 experimental, 2 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L54 | Structure of SMG189 | electron microscopy | B | — | 4 (best 0.83) |
| 6L54 | Structure of SMG189 | electron microscopy | B | — | — |
| 6SYT | Structure of the SMG1-SMG8-SMG9 complex | electron microscopy | B | — | 4 (best 0.85) |
| 6SYT | Structure of the SMG1-SMG8-SMG9 complex | electron microscopy | B | — | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | electron microscopy | B | — | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-lsq | electron microscopy | B | — | — |
| 7PW4 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | B | — | 3 (best 0.83) |
| 7PW4 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | B | — | — |
| 7PW8 | Human SMG1-8-9 kinase complex bound to AMPPNP | electron microscopy | B | — | 3 (best 0.88) |
| 7PW8 | Human SMG1-8-9 kinase complex bound to amppnp | electron microscopy | B | — | — |
| Q8ND04 | AlphaFold monomer V2.0 prediction for protein SMG8 (Q8ND04) | — | — | — | |
| 7PW5 | Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor | electron microscopy | B | — | 4 (best 0.83) |
| 7PW5 | Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C- terminus, bound to a SMG1 inhibitor | electron microscopy | B | — | — |
Experiment against prediction
- 7PW4 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.18 Å
- 7PW4 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.18 Å
- 7PW4 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.18 Å
- 7PW4 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.18 Å
- 7PW8 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.36 Å
- 7PW8 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.36 Å
- 7PW8 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.36 Å
- 7PW8 chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.36 Å
- 6Z3R chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.45 Å
- 6Z3R chain B against the predicted model 7PW5: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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