UniProt Q96Q15
Serine/threonine-protein kinase SMG1 (Q96Q15)
Serine/threonine-protein kinase SMG1 (UniProt Q96Q15), EC 2.7.11.1: 18 experimental structures and 2 predicted models on GenesisL1, 3 ligands bound, 164 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96Q15
- Protein
- Serine/threonine-protein kinase SMG1
- EC
- 2.7.11.1
- Experimental structures
- 18
- Predicted models
- 2
- Ligands
- 3
- Pockets
- 164 · 9 records with a druggable one
Structures
20 records of Q96Q15 in the MolNFT archive: 18 experimental, 2 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L53 | Structure of SMG1 | electron microscopy | A | — | 20 (best 0.83) |
| 6L53 | Structure of SMG1 | electron microscopy | A | — | — |
| 6L54 | Structure of SMG189 | electron microscopy | A | — | 18 (best 0.86) |
| 6L54 | Structure of SMG189 | electron microscopy | A | — | — |
| 6SYT | Structure of the SMG1-SMG8-SMG9 complex | electron microscopy | A | IHP | 17 (best 0.85) |
| 6SYT | Structure of the SMG1-SMG8-SMG9 complex | electron microscopy | A | IHP | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | electron microscopy | A | ANP, IHP | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-lsq | electron microscopy | A | ANP, IHP | — |
| 7PW4 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | A | IHP, 88C | 18 (best 0.84) |
| 7PW4 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | A | IHP, 88C | — |
| 7PW6 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body | electron microscopy | A | IHP, 88C | 18 (best 0.84) |
| 7PW6 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body | electron microscopy | A | IHP, 88C | — |
| 7PW7 | Human SMG1-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | A | IHP, 88C | — |
| 7PW7 | Human SMG1-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | A | IHP, 88C | — |
| 7PW8 | Human SMG1-8-9 kinase complex bound to AMPPNP | electron microscopy | A | IHP, ANP | 18 (best 0.81) |
| 7PW8 | Human SMG1-8-9 kinase complex bound to amppnp | electron microscopy | A | IHP, ANP | — |
| 7PW9 | Human SMG1-9 kinase complex bound to AMPPNP | electron microscopy | A | ANP, IHP | 19 (best 0.82) |
| 7PW9 | Human SMG1-9 kinase complex bound to amppnp | electron microscopy | A | ANP, IHP | 19 (best 0.82) |
| 7PW5 | Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor | electron microscopy | A | IHP, 88C | 17 (best 0.84) |
| 7PW5 | Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C- terminus, bound to a SMG1 inhibitor | electron microscopy | A | IHP, 88C | — |
Ligands
Experiment against prediction
- 7PW4 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.03 Å
- 7PW4 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.03 Å
- 7PW4 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.03 Å
- 7PW4 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.03 Å
- 7PW7 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.37 Å
- 7PW7 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.37 Å
- 7PW7 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.37 Å
- 7PW7 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.37 Å
- 7PW8 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.38 Å
- 7PW8 chain A against the predicted model 7PW5: TM-score 1.00, RMSD 0.38 Å
Elsewhere
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