UniProt Q9H0W8
Nonsense-mediated mRNA decay factor SMG9 (Q9H0W8)
Nonsense-mediated mRNA decay factor SMG9 (UniProt Q9H0W8): 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9H0W8
- Protein
- Nonsense-mediated mRNA decay factor SMG9
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 3 records with a druggable one
Structures
13 records of Q9H0W8 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6L54 | Structure of SMG189 | electron microscopy | C | GTP, MG | — |
| 6SYT | Structure of the SMG1-SMG8-SMG9 complex | electron microscopy | C | ATP, MG | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | electron microscopy | C | ATP, MG | — |
| 6Z3R | Structure of SMG1-8-9 kinase complex bound to UPF1-lsq | electron microscopy | C | ATP, MG | — |
| 7PW4 | Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | C | ATP, MG | — |
| 7PW7 | Human SMG1-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | C | ATP, MG | — |
| 7PW7 | Human SMG1-9 kinase complex bound to a SMG1 inhibitor | electron microscopy | C | ATP, MG | — |
| 7PW8 | Human SMG1-8-9 kinase complex bound to amppnp | electron microscopy | C | ATP, MG | — |
| 7PW9 | Human SMG1-9 kinase complex bound to AMPPNP | electron microscopy | C | ATP, MG | 4 (best 0.72) |
| 7PW9 | Human SMG1-9 kinase complex bound to amppnp | electron microscopy | C | ATP, MG | 4 (best 0.72) |
| 8FE7 | Crystal structure of human O-GlcNAc transferase (OGT) in complex with an exosite-binding peptide… | x-ray diffraction | B, D, F, H | — | 2 (best 0.61) |
| Q9H0W8 | AlphaFold monomer V2.0 prediction for protein SMG9 (Q9H0W8) | — | — | — | |
| 7PW5 | Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C- terminus, bound to a SMG1 inhibitor | electron microscopy | C | ATP, MG | — |
Ligands
Experiment against prediction
- 7PW4 chain C against the predicted model 7PW5: TM-score 1.00, RMSD 0.00 Å
- 7PW8 chain C against the predicted model 7PW5: TM-score 1.00, RMSD 0.38 Å
- 6Z3R chain C against the predicted model 7PW5: TM-score 1.00, RMSD 0.45 Å
- 6Z3R chain C against the predicted model 7PW5: TM-score 1.00, RMSD 0.45 Å
- 6SYT chain C against the predicted model 7PW5: TM-score 0.99, RMSD 0.56 Å
- 7PW7 chain C against the predicted model 7PW5: TM-score 0.98, RMSD 0.90 Å
- 7PW7 chain C against the predicted model 7PW5: TM-score 0.98, RMSD 0.90 Å
- 7PW9 chain C against the predicted model 7PW5: TM-score 0.98, RMSD 0.98 Å
- 7PW9 chain C against the predicted model 7PW5: TM-score 0.98, RMSD 0.98 Å
- 6L54 chain C against the predicted model 7PW5: TM-score 0.95, RMSD 1.16 Å
Elsewhere
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