MolNFT v1 · #185307 · protein
Ternary signalling complex of BMP10 bound to ALK1 and bmprii
7PPC · Bone morphogenetic protein 10: “Ternary signalling complex of BMP10 bound to ALK1 and bmprii”. X-ray diffraction, 14 pockets (best druggability 0.72). MolNFT v1 #185307 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7PPC
- Type
- protein
- Length
- 1,049 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone morphogenetic protein 10; SERINE/THREONINE-protein kinase receptor R3; Bone…
- EC
- 2.7.11.30
- UniProt
- O95393, P37023, Q13873
- Pockets
- 14 · best druggability 0.72
Structure
x-ray diffraction · 7 distinct chains · 8% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Bone morphogenetic protein 10 | protein | 104 | 17% helix, 52% strand | O95393 |
| E | SERINE/THREONINE-protein kinase receptor R3 (EC 2.7.11.30) | protein | 77 | 6% helix, 32% strand | P37023 |
| F, G, H | SERINE/THREONINE-protein kinase receptor R3 (EC 2.7.11.30) | protein | 76 | 7% helix, 37% strand | P37023 |
| I | Bone morphogenetic protein receptor type-2 (EC 2.7.11.30) | protein | 85 | 7% helix, 44% strand | Q13873 |
| J | Bone morphogenetic protein receptor type-2 (EC 2.7.11.30) | protein | 78 | 4% helix, 32% strand | Q13873 |
| K | Bone morphogenetic protein receptor type-2 (EC 2.7.11.30) | protein | 86 | 7% helix, 36% strand | Q13873 |
| L | Bone morphogenetic protein receptor type-2 (EC 2.7.11.30) | protein | 79 | 4% helix, 39% strand | Q13873 |
Pockets
14 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.72 | 0.88 | 34 | empty |
| 2 | 200 | 0.69 | 0.87 | 33 | empty |
| 3 | 228 | 0.69 | 0.85 | 32 | empty |
| 4 | 190 | 0.67 | 0.86 | 31 | empty |
| 5 | 521 | 0.62 | 0.75 | 33 | empty |
Interfaces
17 interfaces between chains.
- A–B · 1476 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1453 Ų buried · 10 hydrogen bonds · protein-protein
- B–J · 956 Ų buried · 5 hydrogen bonds · protein-protein
- C–K · 882 Ų buried · 3 hydrogen bonds · protein-protein
- D–L · 861 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 54 disulfide (disulfide).
Compared structures
- 7PPC · Ternary signalling complex of BMP10 bound to ALK1 and BMPRII · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95393
- Every structure of UniProt P37023
- Every structure of UniProt Q13873
- Elsewhere: RCSB PDB 7PPC · PDBe 7PPC · UniProt O95393 · UniProt P37023 · UniProt Q13873
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