UniProt P37023
Serine/threonine-protein kinase receptor R3 (P37023)
Serine/threonine-protein kinase receptor R3 (UniProt P37023), EC 2.7.11.30: 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P37023
- Protein
- Serine/threonine-protein kinase receptor R3
- EC
- 2.7.11.30
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 2 records with a druggable one
Structures
13 records of P37023 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LCR | NMR Structure of Alk1 extracellular domain | solution nmr | A | — | — |
| 2LCR | NMR structure of ALK1 extracellular domain | solution nmr | A | — | — |
| 3MY0 | Crystal structure of the ACVRL1 (ALK1) kinase domain bound to LDN-193189 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 3MY0 | Crystal structure of the ACVRL1 (ALK1) kinase domain bound to ldn- 193189 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 4FAO | Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex | x-ray diffraction | C, D, I, J, O, P, U, V, c, d, i, j | — | — |
| 4FAO | Specificity and structure of a high affinity activin-like 1 (ALK1) signaling complex | x-ray diffraction | C, D, I, J, O, P, U, V, c, d, i, j | — | — |
| 6SF1 | Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like… | x-ray diffraction | A | NI | 1 (best 0.68) |
| 6SF1 | Bone morphogenetic protein 10 (BMP10) complexed with extracellular domain of activin receptor-like… | x-ray diffraction | A | NI | — |
| 6SF2 | Ternary complex of human bone morphogenetic protein 9 (BMP9) growth factor domain, its prodomain… | x-ray diffraction | A, D | — | — |
| 6SF3 | Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like… | x-ray diffraction | A | — | 3 (best 0.72) |
| 6SF3 | Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like… | x-ray diffraction | A | — | — |
| 7PPC | Ternary signalling complex of BMP10 bound to ALK1 and bmprii | x-ray diffraction | E, F, G, H | — | — |
| P37023 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase receptor R3 (P37023) | predicted | A | — | — |
Ligands
- NI · Nickel (II) ion · in 2 records
Experiment against prediction
- 3MY0 chain J against the predicted model P37023: TM-score 0.98, RMSD 0.98 Å
- 3MY0 chain J against the predicted model P37023: TM-score 0.98, RMSD 0.98 Å
- 3MY0 chain B against the predicted model P37023: TM-score 0.97, RMSD 1.53 Å
- 3MY0 chain B against the predicted model P37023: TM-score 0.97, RMSD 1.53 Å
- 3MY0 chain M against the predicted model P37023: TM-score 0.96, RMSD 1.61 Å
- 3MY0 chain M against the predicted model P37023: TM-score 0.96, RMSD 1.61 Å
- 3MY0 chain W against the predicted model P37023: TM-score 0.96, RMSD 1.68 Å
- 3MY0 chain W against the predicted model P37023: TM-score 0.96, RMSD 1.68 Å
- 3MY0 chain X against the predicted model P37023: TM-score 0.96, RMSD 1.50 Å
- 3MY0 chain X against the predicted model P37023: TM-score 0.96, RMSD 1.50 Å
Elsewhere
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