Crystal structure of 14-3-3 sigma in complex with phosphorylated and farnesylated RND3 peptide

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Ligands and binding sites

• FAR · Farnesyl · ligand · chains A, B
• MG · Magnesium ion · metal · chains A
• CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 541 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified, 1 lipid (farnesylation, oxidation, phosphorylation).

Compared structures

• 7OBC · Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3… · the same entry in another collection · chain A against A, TM-score 1.00
• P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
• P61587 · AlphaFold monomer V2.0 prediction for rho-related GTP-binding protein rhoe (P61587) · a predicted model of the same protein · chain B against A, TM-score 0.60

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P31947
• Every structure of UniProt P61587
• Elsewhere: RCSB PDB 7OBC · PDBe 7OBC · UniProt P31947 · UniProt P61587