MolNFT v1 · #183626 · protein
Cryo-EM structure of human integrin ALPHA5BETA1 in the half-bent conformation
7NXD: “Cryo-EM structure of human integrin ALPHA5BETA1 in the half-bent conformation”. Electron microscopy, 5 ligands (NAG, BMA, MAN). MolNFT v1 #183626 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7NXD
- Type
- protein
- Length
- 1,595 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P08648, P05556
- Ligands
- NAG, BMA, MAN, CA, MG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 905 | — | P08648 |
| B | — | protein | 690 | — | P05556 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 30 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 7 copies
- MAN · alpha-D-mannopyranose · sugar · 3 copies · chains A
- CA · Calcium ion · metal · 7 copies · chains A, B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7NXD · Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation · the same entry in another collection · chain A against A, TM-score 1.00
- P05556 · AlphaFold monomer V2.0 prediction for integrin beta-1 (P05556) · a predicted model of the same protein · chain B against A, TM-score 0.72
- P08648 · AlphaFold monomer V2.0 prediction for integrin alpha-5 (P08648) · a predicted model of the same protein · chain A against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08648
- Every structure of UniProt P05556
- Elsewhere: RCSB PDB 7NXD · PDBe 7NXD · UniProt P08648 · UniProt P05556
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