UniProt P05556
Integrin beta-1 (P05556)
Integrin beta-1 (UniProt P05556): 24 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P05556
- Protein
- Integrin beta-1
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 31 · 3 records with a druggable one
Structures
25 records of P05556 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3G9W | Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail | x-ray diffraction | C, D | — | — |
| 3G9W | Crystal structure of TALIN2 F2-F3 in complex with the integrin BETA1D cytoplasmic tail | x-ray diffraction | C, D | — | — |
| 3T9K | Crystal Structure of ACAP1 C-portion mutant S554D fused with integrin beta1 peptide | x-ray diffraction | A, B | — | — |
| 3T9K | Crystal structure of ACAP1 C-portion mutant S554D fused with integrin BETA1 peptide | x-ray diffraction | A, B | — | — |
| 3VI3 | Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) | x-ray diffraction | B, D | — | — |
| 3VI3 | Crystal structure of ALPHA5BETA1 integrin headpiece (ligand-free form) | x-ray diffraction | B, D | — | — |
| 3VI4 | Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide | x-ray diffraction | B, D | — | — |
| 3VI4 | Crystal structure of ALPHA5BETA1 integrin headpiece in complex with rgd peptide | x-ray diffraction | B, D | — | — |
| 4DX9 | ICAP1 in complex with integrin beta 1 cytoplasmic tail | x-ray diffraction | l, n, x, D, 8, H, p, B, 9, F, r, J, 7, L, 6, N, P, t, v, b, d, f, h, j, R, T, V, X, Z, z | — | — |
| 4DX9 | ICAP1 in complex with integrin beta 1 cytoplasmic tail | x-ray diffraction | l, n, x, D, 8, H, p, B, 9, F, r, J, 7, L, 6, N, P, t, v, b, d, f, h, j, R, T, V, X, Z, z | — | — |
| 4WJK | Metal Ion and Ligand Binding of Integrin | x-ray diffraction | B | — | — |
| 4WJK | Metal ion and ligand binding of integrin | x-ray diffraction | B | — | — |
| 4WK0 | Metal ion and ligand binding of integrin | x-ray diffraction | B | — | — |
| 4WK2 | Metal Ion and Ligand Binding of Integrin | x-ray diffraction | B | — | — |
| 4WK2 | Metal ion and ligand binding of integrin | x-ray diffraction | B | — | — |
| 4WK4 | Metal Ion and Ligand Binding of Integrin | x-ray diffraction | B | — | — |
| 4WK4 | Metal ion and ligand binding of integrin | x-ray diffraction | B | — | — |
| 7CEB | Crystal structure of ALPHA6BETA1 integrin headpiece | x-ray diffraction | B | CA, MG, NAG | — |
| 7CEC | Structure of alpha6beta1 integrin in complex with laminin-511 | electron microscopy | B | MN, NAG | 10 (best 0.85) |
| 7CEC | Structure of ALPHA6BETA1 integrin in complex with laminin-511 | electron microscopy | B | MN, NAG | — |
| 7NWL | Cryo-EM structure of human integrin ALPHA5BETA1 (open form) in complex with fibronectin and TS2/16… | electron microscopy | B | NAG, MN | — |
| 7NXD | Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation | electron microscopy | B | NAG, MG, CA | 14 (best 0.83) |
| 7NXD | Cryo-EM structure of human integrin ALPHA5BETA1 in the half-bent conformation | electron microscopy | B | NAG, MG, CA | — |
| 8W30 | Crystal structure of alpha-V beta-1 integrin headpiece in complex with TR01225179 | x-ray diffraction | B | CA, NAG, A1AFA | 7 (best 0.78) |
| P05556 | AlphaFold monomer V2.0 prediction for integrin beta-1 (P05556) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4DX9 chain j against the predicted model P05556: TM-score 0.99, RMSD 0.04 Å
- 4DX9 chain j against the predicted model P05556: TM-score 0.99, RMSD 0.04 Å
- 4WJK chain B against the predicted model P05556: TM-score 0.98, RMSD 1.05 Å
- 4WJK chain B against the predicted model P05556: TM-score 0.98, RMSD 1.05 Å
- 8W30 chain B against the predicted model P05556: TM-score 0.97, RMSD 1.14 Å
- 3T9K chain B against the predicted model Q15027: TM-score 0.97, RMSD 1.31 Å
- 3T9K chain B against the predicted model Q15027: TM-score 0.97, RMSD 1.31 Å
- 4WK0 chain B against the predicted model P05556: TM-score 0.97, RMSD 1.36 Å
- 4WK2 chain B against the predicted model P05556: TM-score 0.96, RMSD 1.47 Å
- 4WK2 chain B against the predicted model P05556: TM-score 0.96, RMSD 1.47 Å
Elsewhere
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