UniProt P08648
Integrin alpha-5 (P08648)
Integrin alpha-5 (UniProt P08648): 16 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08648
- Protein
- Integrin alpha-5
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 36 · 3 records with a druggable one
Structures
17 records of P08648 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3VI3 | Crystal structure of alpha5beta1 integrin headpiece (ligand-free form) | x-ray diffraction | A, C | — | — |
| 3VI3 | Crystal structure of ALPHA5BETA1 integrin headpiece (ligand-free form) | x-ray diffraction | A, C | — | — |
| 3VI4 | Crystal structure of alpha5beta1 integrin headpiece in complex with RGD peptide | x-ray diffraction | A, C | — | — |
| 3VI4 | Crystal structure of ALPHA5BETA1 integrin headpiece in complex with rgd peptide | x-ray diffraction | A, C | — | — |
| 4WJK | Metal Ion and Ligand Binding of Integrin | x-ray diffraction | A | — | — |
| 4WJK | Metal ion and ligand binding of integrin | x-ray diffraction | A | — | — |
| 4WK0 | Metal ion and ligand binding of integrin | x-ray diffraction | A | — | — |
| 4WK2 | Metal Ion and Ligand Binding of Integrin | x-ray diffraction | A | — | — |
| 4WK2 | Metal ion and ligand binding of integrin | x-ray diffraction | A | — | — |
| 4WK4 | Metal Ion and Ligand Binding of Integrin | x-ray diffraction | A | — | — |
| 4WK4 | Metal ion and ligand binding of integrin | x-ray diffraction | A | — | — |
| 7NWL | Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16… | electron microscopy | A | NAG, MAN, MN | 12 (best 0.83) |
| 7NWL | Cryo-EM structure of human integrin ALPHA5BETA1 (open form) in complex with fibronectin and TS2/16… | electron microscopy | A | NAG, MAN, MN | — |
| 7NXD | Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation | electron microscopy | A | NAG, MAN, CA | 15 (best 0.83) |
| 7NXD | Cryo-EM structure of human integrin ALPHA5BETA1 in the half-bent conformation | electron microscopy | A | NAG, MAN, CA | — |
| 9CKV | Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin | electron microscopy | A | NAG, BMA, MAN, CA | 9 (best 0.81) |
| P08648 | AlphaFold monomer V2.0 prediction for integrin alpha-5 (P08648) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4WK2 chain A against the predicted model P08648: TM-score 0.99, RMSD 0.86 Å
- 4WK2 chain A against the predicted model P08648: TM-score 0.99, RMSD 0.86 Å
- 4WK4 chain A against the predicted model P08648: TM-score 0.99, RMSD 0.94 Å
- 4WK4 chain A against the predicted model P08648: TM-score 0.99, RMSD 0.94 Å
- 4WJK chain A against the predicted model P08648: TM-score 0.99, RMSD 0.94 Å
- 4WJK chain A against the predicted model P08648: TM-score 0.99, RMSD 0.94 Å
- 4WK0 chain A against the predicted model P08648: TM-score 0.99, RMSD 0.97 Å
- 9CKV chain A against the predicted model P08648: TM-score 0.99, RMSD 1.00 Å
- 3VI4 chain C against the predicted model P08648: TM-score 0.98, RMSD 1.26 Å
- 3VI4 chain C against the predicted model P08648: TM-score 0.98, RMSD 1.26 Å
Elsewhere
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