MolNFT v1 · #183607 · protein
Cryo-EM structure of human integrin ALPHA5BETA1 (open form) in complex with fibronectin and TS2/16 fv-clasp
7NWL: “Cryo-EM structure of human integrin ALPHA5BETA1 (open form) in complex with fibronectin and TS2/16 fv-clasp”. Electron microscopy, 4 ligands (NAG, BMA, MAN). MolNFT v1 #183607 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7NWL
- Type
- protein
- Length
- 1,747 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P08648, P05556, P02751
- Ligands
- NAG, BMA, MAN, MN
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 603 | — | P08648 |
| B | — | protein | 441 | — | P05556 |
| C | — | protein | 368 | — | P02751 |
| D | — | protein | 172 | — | — |
| E | — | protein | 163 | — | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 21 copies · chains A, C, B
- BMA · beta-D-mannopyranose · sugar · 7 copies
- MAN · alpha-D-mannopyranose · sugar · 5 copies · chains A
- MN · Manganese (II) ion · metal · 7 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7NWL · Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin… · the same entry in another collection · chain E against E, TM-score 1.00
- P08648 · AlphaFold monomer V2.0 prediction for integrin alpha-5 (P08648) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P05556 · AlphaFold monomer V2.0 prediction for integrin beta-1 (P05556) · a predicted model of the same protein · chain B against A, TM-score 0.56
- P02751 · AlphaFold monomer V2.0 prediction for fibronectin (P02751) · a predicted model of the same protein · chain C against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08648
- Every structure of UniProt P05556
- Every structure of UniProt P02751
- Elsewhere: RCSB PDB 7NWL · PDBe 7NWL · UniProt P08648 · UniProt P05556 · UniProt P02751
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