MolNFT v1 · #183342 · protein
Transactivation domain of P53 in complex with S100P, using annexin A2 as crystallization chaperone
7NMI · Cellular tumor antigen P53: “Transactivation domain of P53 in complex with S100P, using annexin A2 as crystallization chaperone”. X-ray diffraction, 1 ligand (CA), 10 pockets (best druggability 0.58). MolNFT v1 #183342 on GenesisL1…
- PDB
- 7NMI
- Type
- protein
- Length
- 520 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellular tumor antigen P53; S100P-ANXA2 chimera
- UniProt
- P04637, P25815, P07355
- Ligands
- CA
- Pockets
- 10 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellular tumor antigen P53 | protein | 32 | 56% helix, 0% strand | P04637 |
| B | S100P-ANXA2 chimera | protein | 488 | 70% helix, 3% strand | P25815, P07355 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.58 | 0.78 | 41 | empty |
| 2 | 184 | 0.52 | 0.77 | 18 | empty |
| 3 | 89 | 0.49 | 0.82 | 21 | empty |
| 4 | 107 | 0.48 | 0.81 | 27 | GOL |
| 5 | 169 | 0.47 | 0.76 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1409 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7NMI · Transactivation domain of p53 in complex with S100P, using annexin A2 as crystallization… · the same entry in another collection · chain A against A, TM-score 1.00
- P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain B against A, TM-score 0.63
- P25815 · AlphaFold monomer V2.0 prediction for protein S100-P (P25815) · a predicted model of the same protein · chain B against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Every structure of UniProt P25815
- Every structure of UniProt P07355
- Elsewhere: RCSB PDB 7NMI · PDBe 7NMI · UniProt P04637 · UniProt P25815 · UniProt P07355
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