MolNFT v1 · #18275 · protein
Mouse importin alpha-bipartite nls from human retinoblastoma protein complex
1PJM · Retinoblastoma-associated protein: “Mouse importin alpha-bipartite nls from human retinoblastoma protein complex”. X-ray diffraction, 3 pockets (best druggability 0.47). MolNFT v1 #18275 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1PJM
- Type
- protein
- Length
- 447 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinoblastoma-associated protein; Importin alpha-2 subunit
- UniProt
- P06400, P52293
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinoblastoma-associated protein | protein | 20 | 0% helix, 0% strand | P06400 |
| B | Importin alpha-2 subunit | protein | 427 | 73% helix, 0% strand | P52293 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.47 | 0.83 | 13 | empty |
| 2 | 93 | 0.43 | 0.79 | 16 | empty |
| 3 | 58 | 0.35 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1350 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 1PJM · Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P06400 · AlphaFold monomer V2.0 prediction for retinoblastoma-associated protein (P06400) · a predicted model of the same protein · chain A against A, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06400
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 1PJM · PDBe 1PJM · UniProt P06400 · UniProt P52293
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