UniProt P52293
Importin subunit alpha-1 (P52293)
Importin subunit alpha-1 (UniProt P52293), EC 1.11.1.7: 171 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P52293
- Protein
- Importin subunit alpha-1
- EC
- 1.11.1.7
- Experimental structures
- 171
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 13 · 2 records with a druggable one
Structures
172 records of P52293 in the MolNFT archive: 171 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EJL | Mouse importin alpha-SV40 large T antigen nls peptide complex | x-ray diffraction | I | — | — |
| 1EJL | Mouse importin alpha-SV40 large T antigen nls peptide complex | x-ray diffraction | I | — | — |
| 1EJY | Mouse importin alpha-nucleoplasmin nls peptide complex | x-ray diffraction | I | — | — |
| 1EJY | Mouse importin alpha-nucleoplasmin nls peptide complex | x-ray diffraction | I | — | — |
| 1IAL | Importin alpha, mouse | x-ray diffraction | A | — | — |
| 1IAL | Importin alpha, mouse | x-ray diffraction | A | — | — |
| 1IQ1 | Crystal structure of the importin-ALPHA(44-54)-importin-ALPHA(70-529) complex | x-ray diffraction | A, B, C | — | — |
| 1IQ1 | Crystal structure of the importin-ALPHA(44-54)-importin- ALPHA(70-529) complex | x-ray diffraction | A, B, C | — | — |
| 1PJM | Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex | x-ray diffraction | B | — | — |
| 1PJM | Mouse importin alpha-bipartite nls from human retinoblastoma protein complex | x-ray diffraction | B | — | — |
| 1PJN | Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex | x-ray diffraction | A | — | — |
| 1PJN | Mouse importin alpha-bipartite nls N1N2 from xenopus laevis phosphoprotein complex | x-ray diffraction | A | — | — |
| 1Y2A | Structure of mammalian importin bound to the non-classical PLSCR1-NLS | x-ray diffraction | C | — | — |
| 1Y2A | Structure of mammalian importin bound to the non-classical PLSCR1-nls | x-ray diffraction | C | — | — |
| 2C1M | Nup50:importin-alpha complex | x-ray diffraction | A | — | — |
| 2C1M | NUP50:IMPORTIN-alpha complex | x-ray diffraction | A | — | — |
| 3BTR | AR-NLS:Importin-alpha complex | x-ray diffraction | C | — | — |
| 3BTR | Ar-NLS:IMPORTIN-alpha complex | x-ray diffraction | C | — | — |
| 3KND | TPX2:importin-alpha complex | x-ray diffraction | A | — | — |
| 3KND | TPX2:IMPORTIN-alpha complex | x-ray diffraction | A | — | — |
| 3L3Q | Mouse importin alpha-pepTM NLS peptide complex | x-ray diffraction | A | — | — |
| 3L3Q | Mouse importin alpha-peptm nls peptide complex | x-ray diffraction | A | — | — |
| 3OQS | Crystal structure of importin-alpha bound to a CLIC4 NLS peptide | x-ray diffraction | A | — | — |
| 3OQS | Crystal structure of importin-alpha bound to a CLIC4 nls peptide | x-ray diffraction | A | — | — |
| 3Q5U | A minimal NLS from human scramblase 4 complexed with importin alpha | x-ray diffraction | A | — | — |
| 3Q5U | A minimal nls from human scramblase 4 complexed with importin alpha | x-ray diffraction | A | — | — |
| 3RZ9 | Mouse importin alpha-Ku80 NLS peptide complex | x-ray diffraction | A | — | — |
| 3RZ9 | Mouse importin alpha-KU80 nls peptide complex | x-ray diffraction | A | — | — |
| 3RZX | Mouse importin alpha-Ku70 NLS peptide complex | x-ray diffraction | A | — | — |
| 3RZX | Mouse importin alpha-KU70 nls peptide complex | x-ray diffraction | A | — | — |
| 3TPM | Crystal structure of MAL RPEL domain in complex with importin-alpha | x-ray diffraction | A | — | — |
| 3TPM | Crystal structure of mal rpel domain in complex with importin-alpha | x-ray diffraction | A | — | — |
| 3TPO | Crystal structure of D192A/E396A mutant of mouse importin alpha2 | x-ray diffraction | A | — | — |
| 3TPO | Crystal structure of D192A/E396A mutant of mouse importin ALPHA2 | x-ray diffraction | A | — | — |
| 3UKW | Mouse importin alpha: Bimax1 peptide complex | x-ray diffraction | B | — | — |
| 3UKW | Mouse importin alpha: BIMAX1 peptide complex | x-ray diffraction | B | — | — |
| 3UKX | Mouse importin alpha: Bimax2 peptide complex | x-ray diffraction | B | — | — |
| 3UKX | Mouse importin alpha: BIMAX2 peptide complex | x-ray diffraction | B | — | — |
| 3UKY | Mouse importin alpha: yeast CBP80 cNLS complex | x-ray diffraction | B | — | — |
| 3UKY | Mouse importin alpha: yeast CBP80 cnls complex | x-ray diffraction | B | — | — |
| 3UKZ | Mouse importin alpha: mouse CBP80 cNLS complex | x-ray diffraction | B | — | — |
| 3UKZ | Mouse importin alpha: mouse CBP80 cnls complex | x-ray diffraction | B | — | — |
| 3UL0 | Mouse importin alpha: mouse CBP80Y8D cNLS complex | x-ray diffraction | B | — | — |
| 3UL0 | Mouse importin alpha: mouse CBP80Y8D cnls complex | x-ray diffraction | B | — | — |
| 3UL1 | Mouse importin alpha: nucleoplasmin cNLS peptide complex | x-ray diffraction | B | — | — |
| 3UL1 | Mouse importin alpha: nucleoplasmin cnls peptide complex | x-ray diffraction | B | — | — |
| 3UVU | Structural basis of nuclear import of Flap endonuclease 1 (FEN1) | x-ray diffraction | A | — | — |
| 3UVU | Structural basis of nuclear import of flap endonuclease 1 (FEN1) | x-ray diffraction | A | — | — |
| 3VE6 | Crystal Structure Analysis of Venezuelan Equine Encephalitis Virus Capsid Protein NLS and Importin… | x-ray diffraction | A | — | — |
| 3VE6 | Crystal structure analysis of venezuelan equine encephalitis virus capsid protein nls and importin… | x-ray diffraction | A | — | — |
| 3ZIN | Gu_alpha_helicase | x-ray diffraction | A | — | — |
| 3ZIN | GU_ALPHA_HELICASE | x-ray diffraction | A | — | — |
| 3ZIO | minor-site specific NLS (A28) | x-ray diffraction | A | — | — |
| 3ZIO | Minor-site specific nls (A28) | x-ray diffraction | A | — | — |
| 3ZIP | minor-site specific NLS (A58) | x-ray diffraction | A | — | — |
| 3ZIP | Minor-site specific nls (A58) | x-ray diffraction | A | — | — |
| 3ZIQ | minor-site specific NLS (B6) | x-ray diffraction | A | — | — |
| 3ZIQ | Minor-site specific nls (B6) | x-ray diffraction | A | — | — |
| 3ZIR | minor-site specific NLS (B141) | x-ray diffraction | A | — | — |
| 3ZIR | Minor-site specific nls (B141) | x-ray diffraction | A | — | — |
112 records more on the page itself.
Ligands
Experiment against prediction
- 5HUY chain C against the predicted model P52293: TM-score 0.99, RMSD 0.53 Å
- 6BW0 chain E against the predicted model P52293: TM-score 0.99, RMSD 0.59 Å
- 4UAF chain B against the predicted model P52293: TM-score 0.99, RMSD 0.58 Å
- 4UAF chain B against the predicted model P52293: TM-score 0.99, RMSD 0.58 Å
- 3TPM chain A against the predicted model P52293: TM-score 0.99, RMSD 0.55 Å
- 3TPM chain A against the predicted model P52293: TM-score 0.99, RMSD 0.55 Å
- 4YI0 chain C against the predicted model P52293: TM-score 0.99, RMSD 0.60 Å
- 7M60 chain A against the predicted model P52293: TM-score 0.99, RMSD 0.62 Å
- 8FUA chain A against the predicted model P52293: TM-score 0.99, RMSD 0.59 Å
- 4MZ6 chain E against the predicted model P52293: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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