MolNFT v1 · #181359 · protein + DNA
Structure of HIV-1 reverse transcriptase in complex with DNA, L-dttp, and CA(2+) ion
7LSK: “Structure of HIV-1 reverse transcriptase in complex with DNA, L-dttp, and CA(2+) ion”. X-ray diffraction, 6 ligands (XRF, GLC, FRU). MolNFT v1 #181359 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LSK
- Type
- protein + DNA
- Length
- 2,002 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03366
- Ligands
- XRF, GLC, FRU, CA, SO4, NH4
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 554 | — | P03366 |
| B, D | — | protein | 412 | — | P03366 |
| F, E | — | dna | 35 | — | — |
Ligands and binding sites
- XRF · 1-{2-deoxy-5-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}-5-methylpyrimidine-2,4(1H,3H)-dione · ligand · 2 copies · chains A, E, C, F
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains D, B
- FRU · beta-D-fructofuranose · sugar · 2 copies · chains D, B
- CA · Calcium ion · metal · 2 copies · chains A, C
- SO4 · Sulfate ion · ion · 2 copies · chains A, C
- NH4 · Ammonium ion · ion · 2 copies · chains A, C
- GOL · Glycerol · additive · 3 copies · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LSK · Structure of HIV-1 Reverse Transcriptase in complex with DNA, L-dTTP, and CA(2+) ion · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 7LSK · PDBe 7LSK · UniProt P03366
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