UniProt P03366
Reverse transcriptase/ribonuclease H (P03366)
Reverse transcriptase/ribonuclease H (UniProt P03366), EC 2.7.7.-, 2.7.7.49: 617 experimental structures on GenesisL1, 110 ligands bound, 1,661 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P03366
- Protein
- Reverse transcriptase/ribonuclease H
- EC
- 2.7.7.-, 2.7.7.49, 2.7.7.7, 3.1.-.-, 3.1.13.2, 3.1.26.13, 3.1.26.4, 3.4.23.16
- Experimental structures
- 617
- Predicted models
- 0
- Ligands
- 110
- Pockets
- 1,661 · 106 records with a druggable one
Structures
617 records of P03366 in the MolNFT archive: 617 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AJV | HIV-1 protease in complex with the cyclic sulfamide inhibitor AHA006 | x-ray diffraction | A, B | — | — |
| 1AJV | HIV-1 protease in complex with the cyclic sulfamide inhibitor AHA006 | x-ray diffraction | A, B | — | — |
| 1AJX | HIV-1 protease in complex with the cyclic urea inhibitor AHA001 | x-ray diffraction | A, B | — | — |
| 1AJX | HIV-1 protease in complex with the cyclic urea inhibitor AHA001 | x-ray diffraction | A, B | — | — |
| 1AXA | Active-site mobility in human immunodeficiency virus type 1 protease as demonstrated by crystal… | x-ray diffraction | A, B | — | — |
| 1AXA | Active-site mobility in human immunodeficiency virus type 1 protease as demonstrated by crystal… | x-ray diffraction | A, B | — | — |
| 1BQM | HIV-1 RT/HBY 097 | x-ray diffraction | A, B | — | — |
| 1BQM | HIV-1 RT/HBY 097 | x-ray diffraction | A, B | — | — |
| 1BQN | Tyr 188 leu HIV-1 RT/HBY 097 | x-ray diffraction | A, B | — | — |
| 1BQN | Tyr 188 leu HIV-1 RT/HBY 097 | x-ray diffraction | A, B | — | — |
| 1D4H | HIV-1 Protease in complex with the inhibitor BEA435 | x-ray diffraction | A, B | — | — |
| 1D4H | HIV-1 protease in complex with the inhibitor BEA435 | x-ray diffraction | A, B | — | — |
| 1D4I | HIV-1 protease in complex with the inhibitor BEA425 | x-ray diffraction | A, B | — | — |
| 1D4I | HIV-1 protease in complex with the inhibitor BEA425 | x-ray diffraction | A, B | — | — |
| 1D4J | HIV-1 protease in complex with the inhibitor MSL370 | x-ray diffraction | A, B | — | — |
| 1D4J | HIV-1 protease in complex with the inhibitor MSL370 | x-ray diffraction | A, B | — | — |
| 1DLO | Human immunodeficiency virus type 1 | x-ray diffraction | A, B | — | — |
| 1DLO | Human immunodeficiency virus type 1 | x-ray diffraction | A, B | — | — |
| 1DW6 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease | x-ray diffraction | C, D | — | — |
| 1DW6 | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease | x-ray diffraction | C, D | — | — |
| 1EBK | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease | x-ray diffraction | C, D, E, F | — | — |
| 1EBK | Structural and kinetic analysis of drug resistant mutants of HIV-1 protease | x-ray diffraction | C, D, E, F | — | — |
| 1EBW | HIV-1 protease in complex with the inhibitor BEA322 | x-ray diffraction | A, B | — | — |
| 1EBW | HIV-1 protease in complex with the inhibitor BEA322 | x-ray diffraction | A, B | — | — |
| 1EBY | HIV-1 protease in complex with the inhibitor BEA369 | x-ray diffraction | A, B | — | — |
| 1EBY | HIV-1 protease in complex with the inhibitor BEA369 | x-ray diffraction | A, B | — | — |
| 1EBZ | HIV-1 protease in complex with the inhibitor BEA388 | x-ray diffraction | A, B | — | — |
| 1EBZ | HIV-1 protease in complex with the inhibitor BEA388 | x-ray diffraction | A, B | — | — |
| 1EC0 | HIV-1 protease in complex with the inhibitor bea403 | x-ray diffraction | A, B | — | — |
| 1EC0 | HIV-1 protease in complex with the inhibitor BEA403 | x-ray diffraction | A, B | — | — |
| 1EC1 | HIV-1 protease in complex with the inhibitor BEA409 | x-ray diffraction | A, B | — | — |
| 1EC1 | HIV-1 protease in complex with the inhibitor BEA409 | x-ray diffraction | A, B | — | — |
| 1EC2 | HIV-1 protease in complex with the inhibitor BEA428 | x-ray diffraction | A, B | — | — |
| 1EC2 | HIV-1 protease in complex with the inhibitor BEA428 | x-ray diffraction | A, B | — | — |
| 1EC3 | HIV-1 protease in complex with the inhibitor MSA367 | x-ray diffraction | A, B | — | — |
| 1EC3 | HIV-1 protease in complex with the inhibitor MSA367 | x-ray diffraction | A, B | — | — |
| 1EET | HIV-1 reverse transcriptase in complex with the inhibitor MSC204 | x-ray diffraction | A, B | — | — |
| 1EET | HIV-1 reverse transcriptase in complex with the inhibitor MSC204 | x-ray diffraction | A, B | — | — |
| 1HBV | A check on rational drug design. crystal structure of a complex of HIV-1 protease with a novel… | x-ray diffraction | A, B | — | — |
| 1HBV | A check on rational drug design. crystal structure of a complex of HIV-1 protease with a novel… | x-ray diffraction | A, B | — | — |
| 1HEF | The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to… | x-ray diffraction | E | — | — |
| 1HEF | The crystal structures at 2.2 ångströms resolution of hydroxyethylene- based inhibitors bound to… | x-ray diffraction | E | — | — |
| 1HEG | The crystal structures at 2.2 angstroms resolution of hydroxyethylene-based inhibitors bound to… | x-ray diffraction | E | — | — |
| 1HEG | The crystal structures at 2.2 ångströms resolution of hydroxyethylene- based inhibitors bound to… | x-ray diffraction | E | — | — |
| 1HIH | Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with cgp… | x-ray diffraction | A, B | — | — |
| 1HIH | Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with cgp… | x-ray diffraction | A, B | — | — |
| 1HMV | The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1HMV | The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1HNI | Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibitor alpha-apa R… | x-ray diffraction | A | — | — |
| 1HNI | Structure of HIV-1 reverse transcriptase in a complex with the nonnucleoside inhibitor alpha-apa R… | x-ray diffraction | A | — | — |
| 1HNV | Structure of HIV-1 RT(SLASH)TIBO R 86183 complex reveals similarity in the binding of diverse… | x-ray diffraction | A, B | — | — |
| 1HNV | Structure of HIV-1 RT(SLASH)TIBO R 86183 complex reveals similarity in the binding of diverse… | x-ray diffraction | A, B | — | — |
| 1HOS | Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate synthesis and… | x-ray diffraction | A, B | — | — |
| 1HOS | Inhibition of human immunodeficiency virus-1 protease by a C2- symmetric phosphinate synthesis and… | x-ray diffraction | A, B | — | — |
| 1HPS | Rational design, synthesis and crystallographic analysis of a hydroxyethylene-based HIV-1 protease… | x-ray diffraction | A, B | — | — |
| 1HPS | Rational design, synthesis and crystallographic analysis of a hydroxyethylene-based HIV-1 protease… | x-ray diffraction | A, B | — | — |
| 1HPZ | Human immunodeficiency virus type 1 | x-ray diffraction | A, B | — | — |
| 1HPZ | Human immunodeficiency virus type 1 | x-ray diffraction | A, B | — | — |
| 1HQE | Human immunodeficiency virus type 1 | x-ray diffraction | A, B | — | — |
| 1HQE | Human immunodeficiency virus type 1 | x-ray diffraction | A, B | — | — |
557 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 100 records
- MG · Magnesium ion · in 98 records
- FRU · beta-D-fructofuranose · in 27 records
- GLC · alpha-D-glucopyranose · in 27 records
- MN · Manganese (II) ion · in 14 records
- DTP · 2'-deoxyadenosine 5'-triphosphate · in 12 records
- CA · Calcium ion · in 10 records
- D4T · 2',3'-dehydro-2',3'-deoxy-thymidine 5'-triphosphate · in 10 records
- K5C · 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl) amino]piperidin-1-yl}methyl)benzene-1-sulfonamide · in 10 records
- T27 · 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile · in 8 records
- CL · Chloride ion · in 7 records
- K5A · 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide · in 7 records
- CD · Cadmium ion · in 6 records
- NH4 · Ammonium ion · in 6 records
- NVP · 11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-B:2',3'-e][1,4]diazepin-6-one · in 6 records
- M9A · 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile · in 5 records
- 3IR · (1~{R},2~{R})-2-phenyl-~{N}-(1,3-thiazol-2-yl) cyclopropane-1-carboxamide · in 4 records
- 9HY · N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-N-methylacetamide · in 4 records
- 9J1 · N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-N-methylpropanamide · in 4 records
- 9KD · N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)prop-2-enamide · in 4 records
- 9W3 · 4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino}-6-[3-(morpholin-4-yl)propoxy]-1,3,5-triazin-2-yl) amino]benzonitrile · in 4 records
- DDS · 2',3'-dideoxyadenosine triphosphate · in 4 records
- H9Y · 8-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) ethoxy]-4-fluorophenoxy}-6-fluoroindolizine-2-carbonitrile · in 4 records
- NA · Sodium ion · in 4 records
- RFE · L-Methionine Tenofovir · in 4 records
- 2KW · 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile · in 3 records
- 7AY · 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile · in 3 records
- 7N1 · 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) ethoxy]-4-fluorophenoxy}-7-fluoronaphthalene-2-carbonitrile · in 3 records
- 9JP · N-(6-cyano-3-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-4-methylnaphthalen-1-yl)-2-fluoro-N-methylacetamide · in 3 records
- PO4 · Phosphate ion · in 3 records
Elsewhere
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