MolNFT v1 · #180912 · protein
Structure of importin A2 bound to the P50- and P65-nlss
7LET · Importin subunit alpha-1: “Structure of importin A2 bound to the P50- and P65-nlss”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #180912 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LET
- Type
- protein
- Length
- 437 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Nuclear factor nf-kappa-B P105 subunit; Transcription factor P65
- UniProt
- P52293, P19838, Q04206
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Importin subunit alpha-1 | protein | 423 | 75% helix, 0% strand | P52293 |
| B | Nuclear factor nf-kappa-B P105 subunit | protein | 8 | 0% helix, 0% strand | P19838 |
| C | Transcription factor P65 | protein | 6 | 0% helix, 0% strand | Q04206 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.49 | 0.82 | 13 | empty |
| 2 | 55 | 0.32 | 0.77 | 16 | empty |
Interfaces
2 interfaces between chains.
- E–B · 805 Ų buried · 19 hydrogen bonds · protein-protein
- E–C · 657 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 7LET · Structure of importin a2 bound to the p50- and p65-NLSs · the same entry in another collection · chain B against B, TM-score 1.00
- Q04206 · AlphaFold monomer V2.0 prediction for transcription factor P65 (Q04206) · a predicted model of the same protein · chain C against A, TM-score 0.76
- P19838 · AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P19838) · a predicted model of the same protein · chain B against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P19838
- Every structure of UniProt Q04206
- Elsewhere: RCSB PDB 7LET · PDBe 7LET · UniProt P52293 · UniProt P19838 · UniProt Q04206
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.