MolNFT v1 · #180716 · protein
NMR structure of half-calcified calmodulin mutant (CAMEF12) bound to the iq-motif of CAV1.2
7L8V · Calmodulin-1: “NMR structure of half-calcified calmodulin mutant (CAMEF12) bound to the iq-motif of CAV1.2”. Solution nmr, 1 ligand (CA), 3 pockets (best druggability 0.74). MolNFT v1 #180716 on GenesisL1: 3D structure, binding…
- PDB
- 7L8V
- Type
- protein
- Length
- 170 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin-1; Voltage-dependent L-type calcium channel subunit alpha-1C
- UniProt
- P0DP23, Q13936
- Ligands
- CA
- Pockets
- 3 · best druggability 0.74
Structure
solution nmr · 2 distinct chains · 56% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin-1 | protein | 149 | 54% helix, 5% strand | P0DP23 |
| C | Voltage-dependent L-type calcium channel subunit alpha-1C | protein | 21 | 67% helix, 0% strand | Q13936 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.74 | 0.95 | 15 | empty |
| 2 | 122 | 0.58 | 0.84 | 20 | empty |
| 3 | 69 | 0.40 | 0.79 | 21 | empty |
Interfaces
1 interface between chains.
- A–C · 777 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7L8V · NMR Structure of half-calcified calmodulin mutant (CaMEF12) bound to the IQ-motif of… · the same entry in another collection · chain A against A, TM-score 1.00
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain A against A, TM-score 0.47
- Q13936 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain C against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DP23
- Every structure of UniProt Q13936
- Elsewhere: RCSB PDB 7L8V · PDBe 7L8V · UniProt P0DP23 · UniProt Q13936
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