UniProt Q13936
Voltage-dependent L-type calcium channel subunit alpha-1C (Q13936)
Voltage-dependent L-type calcium channel subunit alpha-1C (UniProt Q13936): 29 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 80 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q13936
- Protein
- Voltage-dependent L-type calcium channel subunit alpha-1C
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 80 · 9 records with a druggable one
Structures
30 records of Q13936 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1T0J | Crystal structure of a complex between voltage-gated calcium channel beta2a subunit and a peptide… | x-ray diffraction | C | — | — |
| 1T0J | Crystal structure of a complex between voltage-gated calcium channel BETA2A subunit and a peptide… | x-ray diffraction | C | — | — |
| 2LQC | NMR solution structure of a Ca2+-Calmodulin with a binding motif (NSCaTE) peptide from the… | solution nmr | B | — | — |
| 2LQC | NMR solution structure of a CA2+-calmodulin with a binding motif (nscate) peptide from the… | solution nmr | B | — | — |
| 3G43 | Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer | x-ray diffraction | E, F | — | — |
| 3G43 | Crystal structure of the calmodulin-bound CAV1.2 C-terminal regulatory domain dimer | x-ray diffraction | E, F | — | — |
| 3OXQ | Crystal Structure of Ca2+/CaM-CaV1.2 pre-IQ/IQ domain complex | x-ray diffraction | E, F | — | — |
| 3OXQ | Crystal structure of CA2+/CAM-CAV1.2 pre-IQ/IQ domain complex | x-ray diffraction | E, F | — | — |
| 5V2P | Cav BETA2A subunit: CAV1.2 aid-cap complex | x-ray diffraction | B | 8VY | — |
| 5V2Q | CaV beta2a subunit: CaV1.2 AID-CEN complex | x-ray diffraction | B | 8VY | — |
| 5V2Q | Cav BETA2A subunit: CAV1.2 aid-cen complex | x-ray diffraction | B | 8VY | — |
| 6C0A | Actinin-1 ef-hand bound to the CAV1.2 iq motif | solution nmr | B | — | — |
| 6DAD | 1.65 Angstrom crystal structure of the N97I Ca/CaM:CaV1.2 IQ domain complex | x-ray diffraction | C, D | — | 3 (best 0.58) |
| 6DAD | 1.65 ångström crystal structure of the N97I CA/CAM:CAV1.2 iq domain complex | x-ray diffraction | C, D | — | — |
| 6DAE | 2.0 Angstrom crystal structure of the D95V Ca/CaM:CaV1.2 IQ domain complex | x-ray diffraction | D, C | — | 4 (best 0.60) |
| 6DAE | 2.0 ångström crystal structure of the D95V CA/CAM:CAV1.2 iq domain complex | x-ray diffraction | D, C | — | — |
| 6DAF | 2.4 ångström crystal structure of the F141L CA/CAM:CAV1.2 iq domain complex | x-ray diffraction | C, D | — | — |
| 6U39 | 2.4 ångström crystal structure of the D129G ca-CAM:CAV1.2 iq domain complex | x-ray diffraction | B, D, F, H, J, L, N, P, R, T | — | — |
| 6U3A | 1.65 Angstrom crystal structure of the N97S Ca-CaM:CaV1.2 IQ domain complex | x-ray diffraction | C, D | — | 4 (best 0.69) |
| 6U3A | 1.65 ångström crystal structure of the N97S ca-CAM:CAV1.2 iq domain complex | x-ray diffraction | C, D | — | — |
| 6U3B | 1.7 ångström crystal structure of the Q135P ca-CAM:CAV1.2 iq domain complex | x-ray diffraction | B | CA | — |
| 6U3D | 1.75 Angstrom crystal structure of the N53I Ca-CaM:CaV1.2 IQ domain complex | x-ray diffraction | C, D | — | 3 (best 0.76) |
| 6U3D | 1.75 ångström crystal structure of the N53I ca-CAM:CAV1.2 iq domain complex | x-ray diffraction | C, D | — | — |
| 7L8V | NMR structure of half-calcified calmodulin mutant (CAMEF12) bound to the iq-motif of CAV1.2 | solution nmr | C | — | — |
| 8EOI | Structure of a human EMC:human Cav1.2 channel complex in GDN detergent | electron microscopy | K | 9Z9 | 9 (best 0.75) |
| 8FHS | Human L-type voltage-gated calcium channel Cav1.2 in the presence of amiodarone and sofosbuvir at… | electron microscopy | A | CA, BBI, WG6, 3PE, CLR | 14 (best 0.84) |
| 8WE6 | Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution | electron microscopy | A | CA, 3PE, CLR, NAG, PT5 | 15 (best 0.85) |
| 8WE7 | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom… | electron microscopy | A | CA, CLR, NAG | 14 (best 0.85) |
| 8WE8 | Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and… | electron microscopy | A | CA, CLR, NAG, PT5, 3PE, 6UB | 14 (best 0.85) |
| Q13936 | AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit alpha-1C… | predicted | A | — | — |
Ligands
- CA · Calcium ion · in 5 records
- CLR · Cholesterol · in 4 records
- 3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · in 3 records
- 8VY · 1,3-bis(bromomethyl)benzene · in 3 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- PT5 · (1S)-2-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy) methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate · in 2 records
- 6UB · amlodipine · in 1 record
- 9Z9 · (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en · in 1 record
- BBI · (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone · in 1 record
- WG6 · Sofosbuvir · in 1 record
Experiment against prediction
- 8WE8 chain A against the predicted model Q13936: TM-score 0.97, RMSD 1.77 Å
- 8WE6 chain A against the predicted model Q13936: TM-score 0.97, RMSD 1.90 Å
- 8WE7 chain A against the predicted model Q13936: TM-score 0.97, RMSD 1.93 Å
- 8FHS chain A against the predicted model Q13936: TM-score 0.97, RMSD 1.98 Å
- 8EOI chain K against the predicted model Q13936: TM-score 0.90, RMSD 3.81 Å
- 1T0J chain C against the predicted model Q13936: TM-score 0.89, RMSD 0.18 Å
- 1T0J chain C against the predicted model Q13936: TM-score 0.89, RMSD 0.18 Å
- 3G43 chain F against the predicted model Q13936: TM-score 0.87, RMSD 1.02 Å
- 3G43 chain F against the predicted model Q13936: TM-score 0.87, RMSD 1.02 Å
- 6DAD chain C against the predicted model Q13936: TM-score 0.86, RMSD 0.38 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.