MolNFT v1 · #180533 · protein

Cryo-EM structure of unliganded minimal TRPV1

7L2P: “Cryo-EM structure of unliganded minimal TRPV1”. Electron microscopy, 3 ligands (XJ7, 6IY, NA). MolNFT v1 #180533 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7L2P
Type: protein
Length: 2,234 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O35433
Ligands: XJ7, 6IY, NA

Structure

electron microscopy · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	619	—	O35433
D	—	protein	537	—	O35433
B	—	protein	546	—	O35433
C	—	protein	532	—	O35433

Ligands and binding sites

XJ7 · (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2r,3s,4s,5r, 6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate · ligand · 4 copies · chains A, D, C, B
6IY · (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate · ligand · 4 copies · chains A, D, B, C
NA · Sodium ion · metal · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7L2P · cryo-EM structure of unliganded minimal TRPV1 · the same entry in another collection · chain C against C, TM-score 1.00
O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain C against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35433
Elsewhere: RCSB PDB 7L2P · PDBe 7L2P · UniProt O35433

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.